WDR37_MOUSE
ID WDR37_MOUSE Reviewed; 496 AA.
AC Q8CBE3; Q80Y96; Q8CCL2;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=WD repeat-containing protein 37;
GN Name=Wdr37; Synonyms=Kiaa0982;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryonic tail;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Olfactory bulb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y2I8}. Nucleus
CC {ECO:0000250|UniProtKB:Q9Y2I8}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC98064.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK129254; BAC98064.1; ALT_INIT; mRNA.
DR EMBL; AK032582; BAC27934.1; -; mRNA.
DR EMBL; AK036203; BAC29346.1; -; mRNA.
DR EMBL; BC046236; AAH46236.1; -; mRNA.
DR CCDS; CCDS26232.1; -.
DR RefSeq; NP_001034477.1; NM_001039388.2.
DR RefSeq; NP_766033.1; NM_172445.3.
DR RefSeq; XP_006516532.1; XM_006516469.3.
DR RefSeq; XP_006516533.1; XM_006516470.3.
DR AlphaFoldDB; Q8CBE3; -.
DR SMR; Q8CBE3; -.
DR BioGRID; 228908; 8.
DR IntAct; Q8CBE3; 3.
DR MINT; Q8CBE3; -.
DR STRING; 10090.ENSMUSP00000021572; -.
DR iPTMnet; Q8CBE3; -.
DR PhosphoSitePlus; Q8CBE3; -.
DR EPD; Q8CBE3; -.
DR MaxQB; Q8CBE3; -.
DR PaxDb; Q8CBE3; -.
DR PeptideAtlas; Q8CBE3; -.
DR PRIDE; Q8CBE3; -.
DR ProteomicsDB; 299744; -.
DR Antibodypedia; 23814; 159 antibodies from 21 providers.
DR DNASU; 207615; -.
DR Ensembl; ENSMUST00000021572; ENSMUSP00000021572; ENSMUSG00000021147.
DR Ensembl; ENSMUST00000054251; ENSMUSP00000062174; ENSMUSG00000021147.
DR GeneID; 207615; -.
DR KEGG; mmu:207615; -.
DR UCSC; uc007pki.2; mouse.
DR CTD; 22884; -.
DR MGI; MGI:1920393; Wdr37.
DR VEuPathDB; HostDB:ENSMUSG00000021147; -.
DR eggNOG; KOG0300; Eukaryota.
DR GeneTree; ENSGT00930000150950; -.
DR HOGENOM; CLU_036428_0_0_1; -.
DR InParanoid; Q8CBE3; -.
DR OMA; WDFREAI; -.
DR OrthoDB; 1338925at2759; -.
DR PhylomeDB; Q8CBE3; -.
DR TreeFam; TF105876; -.
DR BioGRID-ORCS; 207615; 4 hits in 74 CRISPR screens.
DR ChiTaRS; Wdr37; mouse.
DR PRO; PR:Q8CBE3; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q8CBE3; protein.
DR Bgee; ENSMUSG00000021147; Expressed in superior cervical ganglion and 234 other tissues.
DR ExpressionAtlas; Q8CBE3; baseline and differential.
DR Genevisible; Q8CBE3; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..496
FT /note="WD repeat-containing protein 37"
FT /id="PRO_0000051388"
FT REPEAT 154..194
FT /note="WD 1"
FT REPEAT 197..236
FT /note="WD 2"
FT REPEAT 281..320
FT /note="WD 3"
FT REPEAT 323..362
FT /note="WD 4"
FT REPEAT 367..405
FT /note="WD 5"
FT REPEAT 408..447
FT /note="WD 6"
FT REPEAT 454..495
FT /note="WD 7"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 69
FT /note="F -> L (in Ref. 2; BAC27934)"
FT /evidence="ECO:0000305"
FT CONFLICT 139
FT /note="T -> I (in Ref. 3; AAH46236)"
FT /evidence="ECO:0000305"
FT CONFLICT 224
FT /note="H -> N (in Ref. 2; BAC27934)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 496 AA; 55046 MW; D647D239E5F6EA08 CRC64;
MPTESGSCST ARQAKQKRKS HSLSIRRTNS SEQERTGLPR EMLEGQDSKL PSSVRSTLLE
LFGQIEREFE NLYIENLELR REIDTLNERL AGEGQAIDGA ELSKGQLKTK ASHSTSQLSQ
KLKTTYKAST SKIVSSFKTT TSRAICQLVK EYIGHRDGIW DVSVTRTQPI VLGTASADHT
ALLWSIETGK CLVKYAGHVG SVNSIKFHPS EQLALTASGD QTAHIWRYVV QLPTPQPVAD
TSQQISGEDE IECSDKDEPD IDGDVSSDCP TVRVPLTSLK SHQGVVIAAD WLVGGKQVVT
ASWDRTANLY DVETSELVHS LTGHDQELTH CCTHPTQRLV VTSSRDTTFR LWDFRDPSIH
SVNVFQGHTD TVTSAVFTVG DNVVSGSDDR TVKVWDLKNM RSPIATIRTD SAINRINVCV
GQKIIALPHD NRQVRLFDMS GVRLARLPRS SRQGHRRMVC CSAWSEDHPI CNLFTCGFDR
QAIGWNINIP ALLQEK
