WDR38_HUMAN
ID WDR38_HUMAN Reviewed; 314 AA.
AC Q5JTN6; A0PK24;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=WD repeat-containing protein 38;
GN Name=WDR38;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ARG-172 AND GLY-193.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AL354928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC127949; AAI27950.1; -; mRNA.
DR CCDS; CCDS43876.1; -.
DR RefSeq; NP_001038941.1; NM_001045476.2.
DR AlphaFoldDB; Q5JTN6; -.
DR SMR; Q5JTN6; -.
DR iPTMnet; Q5JTN6; -.
DR PhosphoSitePlus; Q5JTN6; -.
DR BioMuta; WDR38; -.
DR DMDM; 74755676; -.
DR MassIVE; Q5JTN6; -.
DR PaxDb; Q5JTN6; -.
DR PeptideAtlas; Q5JTN6; -.
DR PRIDE; Q5JTN6; -.
DR Antibodypedia; 64851; 22 antibodies from 12 providers.
DR DNASU; 401551; -.
DR Ensembl; ENST00000373574.2; ENSP00000362677.1; ENSG00000136918.8.
DR GeneID; 401551; -.
DR KEGG; hsa:401551; -.
DR MANE-Select; ENST00000373574.2; ENSP00000362677.1; NM_001045476.3; NP_001038941.1.
DR UCSC; uc004box.5; human.
DR CTD; 401551; -.
DR GeneCards; WDR38; -.
DR HGNC; HGNC:23745; WDR38.
DR HPA; ENSG00000136918; Tissue enriched (fallopian).
DR neXtProt; NX_Q5JTN6; -.
DR OpenTargets; ENSG00000136918; -.
DR PharmGKB; PA162409138; -.
DR VEuPathDB; HostDB:ENSG00000136918; -.
DR eggNOG; KOG0266; Eukaryota.
DR eggNOG; KOG0273; Eukaryota.
DR GeneTree; ENSGT00940000162358; -.
DR HOGENOM; CLU_000288_57_33_1; -.
DR InParanoid; Q5JTN6; -.
DR OMA; RAKCLQV; -.
DR PhylomeDB; Q5JTN6; -.
DR TreeFam; TF328741; -.
DR PathwayCommons; Q5JTN6; -.
DR SignaLink; Q5JTN6; -.
DR BioGRID-ORCS; 401551; 23 hits in 1067 CRISPR screens.
DR ChiTaRS; WDR38; human.
DR GenomeRNAi; 401551; -.
DR Pharos; Q5JTN6; Tdark.
DR PRO; PR:Q5JTN6; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q5JTN6; protein.
DR Bgee; ENSG00000136918; Expressed in bronchial epithelial cell and 87 other tissues.
DR ExpressionAtlas; Q5JTN6; baseline and differential.
DR Genevisible; Q5JTN6; HS.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..314
FT /note="WD repeat-containing protein 38"
FT /id="PRO_0000294440"
FT REPEAT 19..58
FT /note="WD 1"
FT REPEAT 61..100
FT /note="WD 2"
FT REPEAT 103..142
FT /note="WD 3"
FT REPEAT 145..184
FT /note="WD 4"
FT REPEAT 190..228
FT /note="WD 5"
FT REPEAT 231..272
FT /note="WD 6"
FT REPEAT 274..312
FT /note="WD 7"
FT REGION 294..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 172
FT /note="H -> R (in dbSNP:rs2274970)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_053431"
FT VARIANT 193
FT /note="A -> G (in dbSNP:rs10760381)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_053432"
SQ SEQUENCE 314 AA; 34312 MW; 216533C331A83776 CRC64;
MNSGVPATLA VRRVKFFGQH GGEVNSSAFS PDGQMLLTGS EDGCVYGWET RSGQLLWRLG
GHTGPVKFCR FSPDGHLFAS ASCDCTVRLW DVARAKCLRV LKGHQRSVET VSFSPDSRQL
ASGGWDKRVM LWDVQSGQML RLLVGHRDSI QSSDFSPTVN CLATGSWDST VHIWDLRMVT
PAVSHQALEG HSANISCLCY SASGLLASGS WDKTIHIWKP TTSSLLIQLK GHVTWVKSIA
FSPDELWLAS AGYSRMVKVW DCNTGKCLET LKGVLDVAHT CAFTPDGKIL VSGAADQTRR
QISRTSKSPR DPQT
