WDR3_DICDI
ID WDR3_DICDI Reviewed; 942 AA.
AC Q54S79;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=WD repeat-containing protein 3 homolog;
GN Name=wdr3; ORFNames=DDB_G0282623;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR3/UTP12 family. {ECO:0000305}.
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DR EMBL; AAFI02000047; EAL66171.1; -; Genomic_DNA.
DR RefSeq; XP_640160.1; XM_635068.1.
DR AlphaFoldDB; Q54S79; -.
DR SMR; Q54S79; -.
DR STRING; 44689.DDB0233973; -.
DR PaxDb; Q54S79; -.
DR EnsemblProtists; EAL66171; EAL66171; DDB_G0282623.
DR GeneID; 8623698; -.
DR KEGG; ddi:DDB_G0282623; -.
DR dictyBase; DDB_G0282623; wdr3.
DR eggNOG; KOG0306; Eukaryota.
DR HOGENOM; CLU_005318_0_1_1; -.
DR InParanoid; Q54S79; -.
DR OMA; GHQSEVR; -.
DR PhylomeDB; Q54S79; -.
DR Reactome; R-DDI-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:Q54S79; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0034388; C:Pwp2p-containing subcomplex of 90S preribosome; IBA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR GO; GO:0030490; P:maturation of SSU-rRNA; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 4.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR011041; Quinoprot_gluc/sorb_DH.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR007148; SSU_processome_Utp12.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR Pfam; PF04003; Utp12; 1.
DR Pfam; PF00400; WD40; 9.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 12.
DR SUPFAM; SSF50952; SSF50952; 1.
DR SUPFAM; SSF50998; SSF50998; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 9.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..942
FT /note="WD repeat-containing protein 3 homolog"
FT /id="PRO_0000330942"
FT REPEAT 9..52
FT /note="WD 1"
FT REPEAT 57..96
FT /note="WD 2"
FT REPEAT 99..138
FT /note="WD 3"
FT REPEAT 141..180
FT /note="WD 4"
FT REPEAT 183..222
FT /note="WD 5"
FT REPEAT 285..324
FT /note="WD 6"
FT REPEAT 394..432
FT /note="WD 7"
FT REPEAT 434..472
FT /note="WD 8"
FT REPEAT 475..514
FT /note="WD 9"
FT REPEAT 529..568
FT /note="WD 10"
FT REPEAT 571..612
FT /note="WD 11"
FT REPEAT 613..652
FT /note="WD 12"
FT REPEAT 655..694
FT /note="WD 13"
FT REGION 909..942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 909..935
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 942 AA; 107078 MW; 555AE78AF2230BED CRC64;
MVKAYLKFVQ DKVFGLISTS NSILDGSGKL AITGCGERIS IWDLRKQVLN QSLYEEDIKA
EVTNVCLSKD GALLASGYSD GSIRIWSMSD YQLQAVFNGH RGSVTTMTFN RLGNILVSGS
KDTEVIVWDI ITESGLFRLR GHRDQITSVK LLERSNHLIT SSKDGFIKIW DTETQHCIQT
IVGHRNPIWG IDVNPDETRL CSCTSDNQIR FWRIPSNERQ REDGSGIEPK FIVNTPINSA
VIIPDEINED GSKKENSNNS NNNDIDDLEI ISEEEFAKYY GSITVKAESV SGVRFDPTNK
ILAVQSTGKF VDLFKITHYD TMKLEEISIV EEMRHRQTIK TSSKVRFFSF GNDIKHWNKF
VITLAGNSLE AYEIKEKEQG GGAFEVSSTL DQAGHRSDIR SLSLSSNDQM LVSTSSESVK
VWNMKSLSCI RSIACDYGLC TVFAPGNLHV IVGTKTGTIE VFELASAARV ASIKAHEGSV
WSLVLTPDLR GVTSGGADKL VKFWDFELIA SQENSKHKVL NLSLTKTLKV ESDVLALKYS
ADNKFLAVSL LDNTVKIFYT DTVKFHLSLY GHKLPVMCLD ISDDSTLIIT GSADKNIKIW
GLDYGDCHKS FFAHDDSIMQ VSFIPSTHHF ISASKDKRIK YWDADKFEHI QTIEAHHGEV
WSLAMGSVGD FFISGSHDRS IRIFNQTETP IFVESDRQRE MEQTWEATLE DDTRMRTKEM
LEENAAAGKQ TLETIMAGED ILDAIELCVQ EKFKIDEYEK LLKTTKNQDE IPLYQPNIIM
LGLSPSEYLW NRINRIRPSD LEEALRVLPF SVMRTLFEYF NLWVDQSGKS VEFIFKCSFF
LIQTHQNQLS VSTEFIPILQ HLNTSIKNRL QKERFTLGFN RSALSFVKRE IEINQQYKFF
DSDLYLNKNN KNNKDKDSNN NKKDNKKDNK KDNEKSLKRN RK
