WDR3_MOUSE
ID WDR3_MOUSE Reviewed; 942 AA.
AC Q8BHB4;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=WD repeat-containing protein 3;
GN Name=Wdr3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-249, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR3/UTP12 family. {ECO:0000305}.
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DR EMBL; AK050738; BAC34400.1; -; mRNA.
DR EMBL; AK050797; BAC34414.1; -; mRNA.
DR EMBL; BC063100; AAH63100.1; -; mRNA.
DR CCDS; CCDS17674.1; -.
DR RefSeq; NP_780761.1; NM_175552.4.
DR AlphaFoldDB; Q8BHB4; -.
DR SMR; Q8BHB4; -.
DR BioGRID; 234655; 4.
DR STRING; 10090.ENSMUSP00000060613; -.
DR iPTMnet; Q8BHB4; -.
DR PhosphoSitePlus; Q8BHB4; -.
DR SwissPalm; Q8BHB4; -.
DR EPD; Q8BHB4; -.
DR MaxQB; Q8BHB4; -.
DR PaxDb; Q8BHB4; -.
DR PeptideAtlas; Q8BHB4; -.
DR PRIDE; Q8BHB4; -.
DR ProteomicsDB; 297647; -.
DR Antibodypedia; 33896; 95 antibodies from 21 providers.
DR DNASU; 269470; -.
DR Ensembl; ENSMUST00000052120; ENSMUSP00000060613; ENSMUSG00000033285.
DR GeneID; 269470; -.
DR KEGG; mmu:269470; -.
DR UCSC; uc008qqo.2; mouse.
DR CTD; 10885; -.
DR MGI; MGI:2443143; Wdr3.
DR VEuPathDB; HostDB:ENSMUSG00000033285; -.
DR eggNOG; KOG0306; Eukaryota.
DR GeneTree; ENSGT00940000153859; -.
DR HOGENOM; CLU_005318_0_1_1; -.
DR InParanoid; Q8BHB4; -.
DR OMA; GHQSEVR; -.
DR OrthoDB; 459903at2759; -.
DR PhylomeDB; Q8BHB4; -.
DR TreeFam; TF300427; -.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR BioGRID-ORCS; 269470; 27 hits in 78 CRISPR screens.
DR ChiTaRS; Wdr3; mouse.
DR PRO; PR:Q8BHB4; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q8BHB4; protein.
DR Bgee; ENSMUSG00000033285; Expressed in metanephric renal vesicle and 221 other tissues.
DR ExpressionAtlas; Q8BHB4; baseline and differential.
DR Genevisible; Q8BHB4; MM.
DR GO; GO:0031965; C:nuclear membrane; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0034388; C:Pwp2p-containing subcomplex of 90S preribosome; IBA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR GO; GO:0030490; P:maturation of SSU-rRNA; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 4.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR007148; SSU_processome_Utp12.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR Pfam; PF04003; Utp12; 1.
DR Pfam; PF00400; WD40; 8.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 11.
DR SUPFAM; SSF50998; SSF50998; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 9.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW Ubl conjugation; WD repeat.
FT CHAIN 1..942
FT /note="WD repeat-containing protein 3"
FT /id="PRO_0000330941"
FT REPEAT 21..60
FT /note="WD 1"
FT REPEAT 63..102
FT /note="WD 2"
FT REPEAT 105..144
FT /note="WD 3"
FT REPEAT 147..186
FT /note="WD 4"
FT REPEAT 189..228
FT /note="WD 5"
FT REPEAT 277..316
FT /note="WD 6"
FT REPEAT 412..450
FT /note="WD 7"
FT REPEAT 452..490
FT /note="WD 8"
FT REPEAT 493..532
FT /note="WD 9"
FT REPEAT 546..585
FT /note="WD 10"
FT REPEAT 588..629
FT /note="WD 11"
FT REPEAT 630..669
FT /note="WD 12"
FT REPEAT 672..711
FT /note="WD 13"
FT REGION 230..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 723..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..245
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 249
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 725
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UNX4"
FT CROSSLNK 473
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9UNX4"
SQ SEQUENCE 942 AA; 105775 MW; 36F2E83AD4FF85C6 CRC64;
MGLTKQYLRY VASAVFGLIG SQKGNIVFVT LRGEKGRYVA VPACEHVFIW DLRKGEKILI
LQGNKQEVTC LCPSPDGLHL AVGYEDGAIR IFSLLSGEGN ITFNGHKAAV TSLKYDQLGG
RLASGSKDTD VIIWDVINES GLYRLKGHKD AVTQALFLRE RNLLVTSGKD TMVKWWDLDN
QHCFKTMVGH RTEVWGLVLV SEEKRLITGA ADSELRAWDI DYLQEIDDPE EPEPKKIKEC
PGIQDTPESE DSTLEADDEK SEDRILSCSK AGSIMREGRD RVVNLAVDKT GRILACHGTD
SVLEVFCILS KAEVQKKMDK KLKKARKKAR LNSANEEEDP ETSVSMTLQD EILRVAKIKT
SAKIKSFDLI HSPQGELKAV FLLQNNLVEL YSLNASLPAP QPVRTSRITI GGHRSDVRTL
SFSSDNIAVL SAAADSIKIW NRSTLQCIRT MPCEYALCSF FVPGDRQVVI GTKTGNLQLY
DLASGTLLET IAAHDGALWS MSLSPDQRGF VTGGADKAVK FWDFELVTDK NSTQKRLSVK
QTRTLQLDED VLCVSYSPNQ KLLAVSLLDC TVKVFYVDTL KFFLSLYGHK LPVLCMDISH
DGALIATGSA DRNVKIWGLD FGDCHRSLFA HDDSVMYLRF VPKSHLFFTA GKDHKIKQWD
ADKFEHIQTL EGHHQEIWCL AVSPSGDYVV SASHDKSLRL WERTREPLIL EEEREMQREA
EYEESVAKED QPAVPGETQG DNYFTGKKTI ETVKAAERIM EAIELHREET AKMKEHRAIC
KAAGKEVPLP VNPILMAHGN ISPSAYVLET FKGIRSSELE EALLVLPFSY VPDVLTLFNE
FIQTGLDVEL LCRCLFFLLR IHFGQITSNQ MLVPVIEKLK ETTISKVRQV QDAIGFNMAG
LDYLKRECEA KSEVMFFAEA TSHLEEKKKK RKNRKRMILT LT
