位置:首页 > 蛋白库 > WDR41_MOUSE
WDR41_MOUSE
ID   WDR41_MOUSE             Reviewed;         460 AA.
AC   Q3UDP0; Q8C4F1; Q8C8K5;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=WD repeat-containing protein 41 {ECO:0000305};
GN   Name=Wdr41 {ECO:0000312|MGI:MGI:2445123};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=C57BL/6J; TISSUE=Bone marrow, Cerebellum, and Medulla oblongata;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=27617292; DOI=10.1126/sciadv.1601167;
RA   Yang M., Liang C., Swaminathan K., Herrlinger S., Lai F., Shiekhattar R.,
RA   Chen J.F.;
RT   "A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in
RT   autophagy.";
RL   Sci. Adv. 2:E1601167-E1601167(2016).
CC   -!- FUNCTION: Non-catalytic component of the C9orf72-SMCR8 complex, a
CC       complex that has guanine nucleotide exchange factor (GEF) activity and
CC       regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of
CC       GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their
CC       active GTP-bound form, thereby promoting autophagosome maturation. As
CC       part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase
CC       activity in vitro, however WDR42 is shown not be an essential complex
CC       component for this function (By similarity). The C9orf72-SMCR8 complex
CC       also acts as a negative regulator of autophagy initiation by
CC       interacting with the ULK1/ATG1 kinase complex and inhibiting its
CC       protein kinase activity. {ECO:0000250|UniProtKB:Q9HAD4}.
CC   -!- SUBUNIT: Component of the C9orf72-SMCR8 complex, at least composed of
CC       C9orf72, SMCR8 and WDR41. The complex is formed of two protomers, each
CC       individually consisting of one molecule each of C9orf72, SMCR8 and
CC       WDR41 (By similarity). The protomers homodimerize via an interaction
CC       between C9orf72 (via C-terminus) and SMCR8 (via N-terminus) (By
CC       similarity). Within each protomer SMCR8 (via DENN domain) acts as a
CC       bridging protein between WDR41 (via C-terminus and N-terminus) and
CC       C9orf72 (via C-terminus) (By similarity). The C9orf72-SMCR8 complex
CC       associates with the ULK1/ATG1 kinase complex.
CC       {ECO:0000250|UniProtKB:Q9HAD4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27617292}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q3UDP0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q3UDP0-2; Sequence=VSP_016182, VSP_016183;
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK046853; BAC32897.1; -; mRNA.
DR   EMBL; AK082348; BAC38474.1; -; mRNA.
DR   EMBL; AK149993; BAE29221.1; -; mRNA.
DR   CCDS; CCDS56896.2; -. [Q3UDP0-1]
DR   RefSeq; NP_766178.2; NM_172590.3. [Q3UDP0-1]
DR   RefSeq; XP_017170980.1; XM_017315491.1. [Q3UDP0-1]
DR   AlphaFoldDB; Q3UDP0; -.
DR   SMR; Q3UDP0; -.
DR   BioGRID; 230033; 3.
DR   ComplexPortal; CPX-3962; C9orf72-SMCR8 complex.
DR   IntAct; Q3UDP0; 2.
DR   MINT; Q3UDP0; -.
DR   STRING; 10090.ENSMUSP00000138543; -.
DR   iPTMnet; Q3UDP0; -.
DR   PhosphoSitePlus; Q3UDP0; -.
DR   EPD; Q3UDP0; -.
DR   MaxQB; Q3UDP0; -.
DR   PaxDb; Q3UDP0; -.
DR   PeptideAtlas; Q3UDP0; -.
DR   PRIDE; Q3UDP0; -.
DR   ProteomicsDB; 297648; -. [Q3UDP0-1]
DR   ProteomicsDB; 297649; -. [Q3UDP0-2]
DR   Antibodypedia; 24490; 94 antibodies from 18 providers.
DR   DNASU; 218460; -.
DR   Ensembl; ENSMUST00000056512; ENSMUSP00000055145; ENSMUSG00000042015. [Q3UDP0-1]
DR   Ensembl; ENSMUST00000160801; ENSMUSP00000124033; ENSMUSG00000042015. [Q3UDP0-1]
DR   GeneID; 218460; -.
DR   KEGG; mmu:218460; -.
DR   UCSC; uc033gmt.1; mouse. [Q3UDP0-1]
DR   CTD; 55255; -.
DR   MGI; MGI:2445123; Wdr41.
DR   VEuPathDB; HostDB:ENSMUSG00000042015; -.
DR   eggNOG; ENOG502QURA; Eukaryota.
DR   GeneTree; ENSGT00390000017026; -.
DR   HOGENOM; CLU_047570_0_0_1; -.
DR   InParanoid; Q3UDP0; -.
DR   OMA; QLQCHRQ; -.
DR   OrthoDB; 1152122at2759; -.
DR   PhylomeDB; Q3UDP0; -.
DR   TreeFam; TF332914; -.
DR   BioGRID-ORCS; 218460; 2 hits in 71 CRISPR screens.
DR   ChiTaRS; Wdr41; mouse.
DR   PRO; PR:Q3UDP0; -.
DR   Proteomes; UP000000589; Chromosome 13.
DR   RNAct; Q3UDP0; protein.
DR   Bgee; ENSMUSG00000042015; Expressed in interventricular septum and 221 other tissues.
DR   ExpressionAtlas; Q3UDP0; baseline and differential.
DR   Genevisible; Q3UDP0; MM.
DR   GO; GO:1990316; C:Atg1/ULK1 kinase complex; ISO:MGI.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0032045; C:guanyl-nucleotide exchange factor complex; ISO:MGI.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISO:MGI.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0045920; P:negative regulation of exocytosis; IC:ComplexPortal.
DR   GO; GO:0050777; P:negative regulation of immune response; IC:ComplexPortal.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB.
DR   GO; GO:0010506; P:regulation of autophagy; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR040102; WDR41.
DR   PANTHER; PTHR22805; PTHR22805; 1.
DR   Pfam; PF00400; WD40; 2.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   1: Evidence at protein level;
KW   Alternative splicing; Autophagy; Cytoplasm; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..460
FT                   /note="WD repeat-containing protein 41"
FT                   /id="PRO_0000051391"
FT   REPEAT          40..79
FT                   /note="WD 1"
FT   REPEAT          82..128
FT                   /note="WD 2"
FT   REPEAT          131..168
FT                   /note="WD 3"
FT   REPEAT          220..258
FT                   /note="WD 4"
FT   REPEAT          321..359
FT                   /note="WD 5"
FT   REPEAT          403..441
FT                   /note="WD 6"
FT   VAR_SEQ         233..308
FT                   /note="DTGFVTGSHVGELLIWDALDWTVQACERTFWSPTAQLDAQQEIKLFQKQNDI
FT                   SINHFTCDEENIFAAVGRGLYVYN -> GSVLTMGSVLTTGSVLTIGSVLTTGSVLTMG
FT                   SVLTTGSAADRRLCADHGLCADRRLCADHGLCADCRRLCCPQALC (in isoform
FT                   2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_016182"
FT   VAR_SEQ         309..460
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_016183"
FT   CONFLICT        135
FT                   /note="T -> K (in Ref. 1; BAC32897)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   460 AA;  51511 MW;  DADD97BFB0787D0F CRC64;
     MLRWLIGGGR EPQGLAEKAA LQTIGEDQGQ NPYTELLVLE AHRDIVRFLV RLDDFRFASA
     GDDGIIVVWN AQTGEKLLEL RGHTQKITAV IAFPPLDSCE ASSQLLLTAS ADRTVGVWDC
     DTGRQIQRVT CFQSTVKCLT VLQRLDIWLS GGSDLGVWNR KLDLLCKTSH LSDTGISALV
     EIPGNCVAAA VGRELIIFRL VTPTEELPEW DIIEVKRLLD HQDNILSLAN INDTGFVTGS
     HVGELLIWDA LDWTVQACER TFWSPTAQLD AQQEIKLFQK QNDISINHFT CDEENIFAAV
     GRGLYVYNLQ LKRVIACQKT AHDSNILHID KLPNRQLISC SEDGAVRMWE VREKQQLAAE
     PVPTGFFNMW GFGRVNKQAS QPVKKQEENV TTCSLELIGD LIGHSSSVEM FLYFEDHGLV
     TCSADHLIIL WKNGERESGV RSLKLFQKLE ENGDLYPESP
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024