ID   WDR44_XENLA             Reviewed;         912 AA.
AC   Q498F0;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=WD repeat-containing protein 44;
GN   Name=wdr44;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Downstream effector for rab11. May be involved in vesicle
CC       recycling (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cytoplasm, perinuclear
CC       region. Endosome membrane. Golgi apparatus, trans-Golgi network.
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DR   EMBL; BC100241; AAI00242.1; -; mRNA.
DR   RefSeq; NP_001089666.1; NM_001096197.1.
DR   AlphaFoldDB; Q498F0; -.
DR   SMR; Q498F0; -.
DR   BioGRID; 592507; 1.
DR   IntAct; Q498F0; 1.
DR   PRIDE; Q498F0; -.
DR   GeneID; 734726; -.
DR   KEGG; xla:734726; -.
DR   CTD; 734726; -.
DR   Xenbase; XB-GENE-6255294; wdr44.L.
DR   OMA; WHISRSE; -.
DR   OrthoDB; 1332590at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 734726; Expressed in zone of skin and 19 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR040324; WDR44/Dgr2.
DR   PANTHER; PTHR14221; PTHR14221; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endosome; Golgi apparatus; Membrane; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..912
FT                   /note="WD repeat-containing protein 44"
FT                   /id="PRO_0000262772"
FT   REPEAT          511..550
FT                   /note="WD 1"
FT   REPEAT          608..646
FT                   /note="WD 2"
FT   REPEAT          648..688
FT                   /note="WD 3"
FT   REPEAT          693..732
FT                   /note="WD 4"
FT   REPEAT          743..782
FT                   /note="WD 5"
FT   REPEAT          787..826
FT                   /note="WD 6"
FT   REPEAT          841..880
FT                   /note="WD 7"
FT   REPEAT          882..912
FT                   /note="WD 8"
FT   REGION          206..352
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          399..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          460..481
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          559..594
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          861..882
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        238..257
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        258..274
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        288..345
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        559..581
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   912 AA;  101686 MW;  33E1603E50B16ED7 CRC64;
     MASDSDTEEF FDAPEDVNLS CSPAVSPLKS ETFILKEEAT YSKKAETRNI ELKQDDSKEI
     IDSIIEESQK CSDTENENPV VEEKTEVLHE TLIGDSVKTK QDLLSNIPEL VVTESTFHDG
     VEDPLQQQIS EYLEPDISRS QDAGPSADSA YVPSAIENIV DLTQDLKITE ELKIAEEPEI
     PLIQEETKDP SKNIVEDVFS KLPTSDIIEQ LPPAKPPRQI CVEPDIVAST KKSGPNRPPQ
     PINAPPPRPP PPARPAPPPR KKKGDTDFDR SSGFEYQKDG FLAGGLLSPN TLTENMNRDS
     QPSLDLASAT SGEKIVTAQE NGKAADGQLS SQSSECLGPQ RPRSNSGREL TDDEILASVM
     IKNLDTGEEI PLSLAEEKLP TGINPLTLYI MRRTKEYVSN DAAQSDDEEK PQSHQSETDG
     GKLKQKTTQL KKFLGKSVKR AKHLAEEYGE RAVNKVKSVR DEVFHTDQDD PSSSDDEGMP
     YTRPVKFKAA HGFKGPYDFE QIKVVQDLSG EHVGAVWTMK FSHCGRLLAS AGQDNVVRIW
     VLKNAFDYFN NMRIKYNTEG RVSPSPSQES LNSSKSDTDG GVFSGTDDVD PDDKNAPFRQ
     VPFCKYKGHT ADLLDLSWSK NYFLLSSSMD KTVRLWHISR RECLCCFQHI DFVTAIAFHP
     RDDRYFLSGS LDGKLRLWNI PDKKVALWNE IDGQTKLITA ANFCQNGKHA VIGTYDGRCI
     FYDTEHLKYH TQIHVRSTRG RNRVGRKITG IEPLPGENKI LVTSNDSRIR LYDLRDLSLS
     MKYKGCVNSS SQIKASFSHD FTYIVSGSED KYVYIWSTYH DLSKFTSVRR DRNDFWEGIK
     AHNAVVTSAI FAPNPGLMVS AETSSEKQEG DQAEPVENIP SGALKSDHTE VLLSADFTGA
     IKVFINKKKN IS