ID   WDR46_CANLF             Reviewed;         612 AA.
AC   Q5TJE7;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=WD repeat-containing protein 46;
GN   Name=WDR46; Synonyms=C12H6orf11;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Doberman pinscher;
RX   PubMed=15607421; DOI=10.1016/j.ygeno.2004.09.009;
RA   Debenham S.L., Hart E.A., Ashurst J.L., Howe K.L., Quail M.A.,
RA   Ollier W.E.R., Binns M.M.;
RT   "Genomic sequence of the class II region of the canine MHC: comparison with
RT   the MHC of other mammalian species.";
RL   Genomics 85:48-59(2005).
CC   -!- FUNCTION: Scaffold component of the nucleolar structure. Required for
CC       localization of DDX21 and NCL to the granular compartment of the
CC       nucleolus. {ECO:0000250|UniProtKB:O15213}.
CC   -!- SUBUNIT: Interacts with DDX21, NCL, NOP2 and EBNA1BP2.
CC       {ECO:0000250|UniProtKB:O15213}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:O15213}.
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DR   EMBL; AJ630366; CAI11441.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5TJE7; -.
DR   SMR; Q5TJE7; -.
DR   STRING; 9612.ENSCAFP00000001360; -.
DR   PaxDb; Q5TJE7; -.
DR   Ensembl; ENSCAFT00030024261; ENSCAFP00030021163; ENSCAFG00030013122.
DR   Ensembl; ENSCAFT00040038819; ENSCAFP00040033858; ENSCAFG00040020928.
DR   Ensembl; ENSCAFT00845037081; ENSCAFP00845029039; ENSCAFG00845021010.
DR   VEuPathDB; HostDB:ENSCAFG00845021010; -.
DR   VGNC; VGNC:48369; WDR46.
DR   eggNOG; KOG1272; Eukaryota.
DR   GeneTree; ENSGT00390000007075; -.
DR   InParanoid; Q5TJE7; -.
DR   Proteomes; UP000002254; Chromosome 12.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR012952; BING4_C_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR040315; WDR46/Utp7.
DR   PANTHER; PTHR14085; PTHR14085; 1.
DR   Pfam; PF08149; BING4CT; 1.
DR   SMART; SM01033; BING4CT; 1.
DR   SMART; SM00320; WD40; 3.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..612
FT                   /note="WD repeat-containing protein 46"
FT                   /id="PRO_0000051394"
FT   REPEAT          215..273
FT                   /note="WD 1"
FT   REPEAT          275..313
FT                   /note="WD 2"
FT   REPEAT          316..355
FT                   /note="WD 3"
FT   REPEAT          358..397
FT                   /note="WD 4"
FT   REPEAT          400..437
FT                   /note="WD 5"
FT   REGION          1..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          539..612
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..60
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        568..612
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         41
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O15213"
SQ   SEQUENCE   612 AA;  68817 MW;  83FF8A172C56311B CRC64;
     METASKPGRD VQPKKARLQT KKKKPRRYWE KEATLTAAGA SPGPPRNKKR NRELRPQRPK
     NINLPKKSRI PGKPQFPKKP REQRNLEPQR NLSGAQDPFP GPAPIPEEVA RKFRRIDKSK
     KLPHSKSKTR SRLEVAEAEE EEISIKAARS ELLLAEEPGF LEGEDGEDTA KIRQAEIVEA
     VDIASAAKHF DLNLRQFGPY RLNYSPVGRH LAFGGHRGHV ATLDWVTKRL MCEINVMEAV
     RDIRFLHSEA LFAVAQNRWL HIYDNQGIEL HCIRRCDRVT RLEFLPFHFL LATASETGFL
     TYLDVSVGKI VAALNARAGR LDVMTKNPYN AVIHLGHSNG TVSLWSPAMK EPLAKILCHR
     GGVRAVAVDS TGTYMATSGL DHQLKIFDLR GMFQPLSART LPQGAGHLAF SQRGLLAAGM
     SDVVNIWMGQ GMASPPSLEQ PYLTHRLSGH VHGLHFCPFE DVLGLGHSGG ITSMLVPGAA
     EPNFDGLENN PYRSQKQRQE WEVKALLEKV PAELICLDPR ALAEVDVISL EQEKKERIER
     LGYDPEAKAP FQPKPKQKGR SSTASLVKRR RKVMDKEHRD KVRQSLEQQP QKQEKKAKPL
     KARPSALDRF VR