WDR46_MOUSE
ID WDR46_MOUSE Reviewed; 622 AA.
AC Q9Z0H1;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=WD repeat-containing protein 46;
DE AltName: Full=WD repeat-containing protein BING4;
GN Name=Wdr46; Synonyms=Bing4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=129/SvJ;
RA Rowen L., Qin S., Madan A., Loretz C., Hall J., James R., Dors M.,
RA Shaffer T., Abbasi N., Ratcliffe A., Dickhoff R., Lasky S., Hood L.;
RT "Sequence of the mouse major histocompatibility complex class II region.";
RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Scaffold component of the nucleolar structure. Required for
CC localization of DDX21 and NCL to the granular compartment of the
CC nucleolus. {ECO:0000250|UniProtKB:O15213}.
CC -!- SUBUNIT: Interacts with DDX21, NCL, NOP2 and EBNA1BP2.
CC {ECO:0000250|UniProtKB:O15213}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:O15213}.
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DR EMBL; AF110520; AAC97976.1; -; Genomic_DNA.
DR EMBL; AF100956; AAC69896.1; -; Genomic_DNA.
DR EMBL; BC046977; AAH46977.1; -; mRNA.
DR CCDS; CCDS28637.1; -.
DR RefSeq; NP_065628.1; NM_020603.2.
DR AlphaFoldDB; Q9Z0H1; -.
DR SMR; Q9Z0H1; -.
DR BioGRID; 208253; 3.
DR IntAct; Q9Z0H1; 1.
DR MINT; Q9Z0H1; -.
DR STRING; 10090.ENSMUSP00000025170; -.
DR iPTMnet; Q9Z0H1; -.
DR PhosphoSitePlus; Q9Z0H1; -.
DR SwissPalm; Q9Z0H1; -.
DR EPD; Q9Z0H1; -.
DR jPOST; Q9Z0H1; -.
DR MaxQB; Q9Z0H1; -.
DR PaxDb; Q9Z0H1; -.
DR PeptideAtlas; Q9Z0H1; -.
DR PRIDE; Q9Z0H1; -.
DR ProteomicsDB; 299971; -.
DR Antibodypedia; 29045; 57 antibodies from 19 providers.
DR Ensembl; ENSMUST00000025170; ENSMUSP00000025170; ENSMUSG00000024312.
DR GeneID; 57315; -.
DR KEGG; mmu:57315; -.
DR UCSC; uc008cai.1; mouse.
DR CTD; 9277; -.
DR MGI; MGI:1931871; Wdr46.
DR VEuPathDB; HostDB:ENSMUSG00000024312; -.
DR eggNOG; KOG1272; Eukaryota.
DR GeneTree; ENSGT00390000007075; -.
DR HOGENOM; CLU_022996_2_0_1; -.
DR InParanoid; Q9Z0H1; -.
DR OMA; KYTFIYD; -.
DR OrthoDB; 430457at2759; -.
DR PhylomeDB; Q9Z0H1; -.
DR TreeFam; TF300861; -.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR BioGRID-ORCS; 57315; 25 hits in 77 CRISPR screens.
DR ChiTaRS; Wdr46; mouse.
DR PRO; PR:Q9Z0H1; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9Z0H1; protein.
DR Bgee; ENSMUSG00000024312; Expressed in gonadal ridge and 241 other tissues.
DR ExpressionAtlas; Q9Z0H1; baseline and differential.
DR Genevisible; Q9Z0H1; MM.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR012952; BING4_C_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR040315; WDR46/Utp7.
DR PANTHER; PTHR14085; PTHR14085; 1.
DR Pfam; PF08149; BING4CT; 1.
DR SMART; SM01033; BING4CT; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..622
FT /note="WD repeat-containing protein 46"
FT /id="PRO_0000051396"
FT REPEAT 192..233
FT /note="WD 1"
FT REPEAT 234..271
FT /note="WD 2"
FT REPEAT 314..353
FT /note="WD 3"
FT REPEAT 356..395
FT /note="WD 4"
FT REPEAT 398..435
FT /note="WD 5"
FT REGION 1..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..588
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..622
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 41
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15213"
SQ SEQUENCE 622 AA; 69048 MW; B1BF9A36AC612612 CRC64;
METAPKPGRG VPPKRDKPQA KRKKPRRYWE EETTPAAVAT SPGPPRKKAR TGESRPPRSK
SAHIAQKSRF SKKPPISKTA PDWKKPQRTL SGAQDPFPGP VPAPLEEARK FCRIDKSKTL
PHSKPKTQSK LEKAEAQEEE ASVRAARAEL LLAEEPGFLV GEDGEDTAKI LQTDIVEAVD
IASAAKHFDL NLRQFGPYRL NYSRTGRHLA LGGRRGHVAA LDWVTKKLMC EINVMEAVRD
IHFLHSEALL AVAQNRWLYI YDNQGIELHC IRRCDRVTRL EFLPFHFLLA TTSETGFLTY
LDVSVGKIVT ALNVRAGRLS VMAQNPYNAV IHLGHSNGTV SLWSPAVKEP LAKILCHRGG
VRAVAVDSTG TYMATSGLDH QLKIFDLRGT FQPLSSRTLP QGAGHLAFSQ RGLLVAGMGD
VVNIWAGQGK ASPPSLEQPY LTHRLSGHVH GLQFCPFEDV LGVGHSGGFT SMLVPGAAEP
NFDGLENNPY RSRKQRQEWE VKALLEKVPA ELICLNPRAL AEVDVVTLEQ QKKERIERLG
YDPDAKAAFQ PKAKQKGRSS TASLVKRKKK VMDQEHRDKV RQSLEQQQQK KKQDMAMPPG
ARPSALDRFV RRAREGGLQV DP
