ID   WDR48_AEDAE             Reviewed;         659 AA.
AC   Q16MY0;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=WD repeat-containing protein 48 homolog;
GN   ORFNames=AAEL012158;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Regulator of deubiquitinating complexes. Activates
CC       deubiquitination by increasing the catalytic turnover without
CC       increasing the affinity of deubiquitinating enzymes for the substrate
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR48 family. {ECO:0000305}.
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DR   EMBL; CH477846; EAT35694.1; -; Genomic_DNA.
DR   RefSeq; XP_001662285.1; XM_001662235.1.
DR   AlphaFoldDB; Q16MY0; -.
DR   SMR; Q16MY0; -.
DR   STRING; 7159.AAEL012158-PA; -.
DR   VEuPathDB; VectorBase:AAEL021400; -.
DR   eggNOG; KOG0308; Eukaryota.
DR   InParanoid; Q16MY0; -.
DR   OMA; NWFNVDL; -.
DR   PhylomeDB; Q16MY0; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR021772; WDR48/Bun107.
DR   Pfam; PF11816; DUF3337; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..659
FT                   /note="WD repeat-containing protein 48 homolog"
FT                   /id="PRO_0000378975"
FT   REPEAT          27..67
FT                   /note="WD 1"
FT   REPEAT          73..112
FT                   /note="WD 2"
FT   REPEAT          115..154
FT                   /note="WD 3"
FT   REPEAT          166..205
FT                   /note="WD 4"
FT   REPEAT          208..247
FT                   /note="WD 5"
FT   REPEAT          250..289
FT                   /note="WD 6"
FT   REPEAT          292..332
FT                   /note="WD 7"
FT   REPEAT          337..376
FT                   /note="WD 8"
FT   REGION          592..613
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   659 AA;  73706 MW;  847F0800216CFE34 CRC64;
     MLTHKNNQGG RKKMQVSFVI RDAEEKRHRN GVNALQLDTI NGRLYSAGRD AIIRVWNSMQ
     NNSQEPYIQS MEHHNDWVND IVLCCGGRNL ISASCDTTVK VWNAHKGFCM STLRTHRDYV
     QALAYAKDRE QVASAGLDKA IFLWDINTLT ALTASNNTVT TSSITGSKDS IYSLAMNPSG
     TVIVCGSTEN TLRIWDPRTC NKIAKLKGHA ENVKALVVSE DGQHVISGSS DGKIKQWSIG
     QQRCVQTISV HSEGVWALLM TDNFSHVISG SRDKKIIMTD LRNPTNSVLI CEERAPVLSL
     CYNYDQTGVW ATTWNSDIRC WKLNPSEKLS FEVACIKGGA AIKKYHVLND KRFMLTKDSE
     MNVAIYDVLK VKKVEDLGKV DYEEEIKKRS QKVYVPNWFT VDLKTGMPTI VLGQDEVDCF
     AAWVSAEAGL PEHAESGTDP KVNYGSLLLQ ALLEYWKPPP PHHHLQGVGS DLDSNGCDGD
     IRGNEYFSVP KHTPIIFSEV GGRNVCRLLV KDAVGETESA LLSETVPSWV TNVVIERTIP
     KFIKLPFYLL AHPSMLKQDR SKKERLIANE FIQCRKVCEH VLEKVLGADL PASTGNSNSS
     QNNSQSDANS EGSQVPAEER IELLCNDVIC DPNMDLRTVR HFIWKQSSDL TFHYRTKSN