ID   WDR48_BRUMA             Reviewed;         660 AA.
AC   A8Q2R5;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 2.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=WD repeat-containing protein 48 homolog;
GN   ORFNames=Bm1_41555;
OS   Brugia malayi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17885136; DOI=10.1126/science.1145406;
RA   Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA   Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA   Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA   Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA   Pop M., White O., Barton G.J., Carlow C.K.S., Crawford M.J., Daub J.,
RA   Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA   Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.-W.,
RA   Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA   McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA   Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA   Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA   Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA   Blaxter M.L., Scott A.L.;
RT   "Draft genome of the filarial nematode parasite Brugia malayi.";
RL   Science 317:1756-1760(2007).
CC   -!- FUNCTION: Regulator of deubiquitinating complexes. Activates
CC       deubiquitination by increasing the catalytic turnover without
CC       increasing the affinity of deubiquitinating enzymes for the substrate
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR48 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDP31490.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; DS239412; EDP31490.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001899768.1; XM_001899733.1.
DR   AlphaFoldDB; A8Q2R5; -.
DR   SMR; A8Q2R5; -.
DR   STRING; 6279.A8Q2R5; -.
DR   GeneID; 6103192; -.
DR   CTD; 6103192; -.
DR   WormBase; Bm3846a; BM22799; WBGene00224107; Bma-wdr-48.
DR   InParanoid; A8Q2R5; -.
DR   OrthoDB; 261328at2759; -.
DR   Proteomes; UP000006672; Unassembled WGS sequence.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR021772; WDR48/Bun107.
DR   Pfam; PF11816; DUF3337; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..660
FT                   /note="WD repeat-containing protein 48 homolog"
FT                   /id="PRO_0000378976"
FT   REPEAT          23..78
FT                   /note="WD 1"
FT   REPEAT          84..120
FT                   /note="WD 2"
FT   REPEAT          123..162
FT                   /note="WD 3"
FT   REPEAT          174..213
FT                   /note="WD 4"
FT   REPEAT          216..255
FT                   /note="WD 5"
FT   REPEAT          258..297
FT                   /note="WD 6"
FT   REPEAT          300..341
FT                   /note="WD 7"
FT   REPEAT          362..401
FT                   /note="WD 8"
SQ   SEQUENCE   660 AA;  74668 MW;  928CE667745B74EC CRC64;
     MTAIPVKKKV QVSFVIRDEK EPMHRSGVNC LQYDAQTGRL FSGGSDTIIR IWKSPDRKDD
     SGSSYSVGGK TRVRRDLHLQ SMEHHTDWVN DIVLCCGVIS ASSDTTVKVW NAQKGFCMST
     LRTHRDYVRA LAYARDVEMV ASGGFDQLIY LWDIATLTKL TALNNTVTTS SLTGNKDSIY
     SLATNPSGTV VISGSTEKVL RVFDPRACQK LMKLRGHTDN VKAVVVNRDG TQCISASSDG
     TIKLWSIGQQ CCISSLKCHS ESVWALQVDS NFSCVYSGGR DKRIFRTAIN DFKTAQLMFI
     EDAPVQRLQL IDSESRFIWT ATWNSSIKRW PLPSDAQISV EIKSDQYGET IPSIHEPDLT
     IPGAASIRQH VVLNDKRHIV TKDTDDNVAM WDVLKGRKVC DHGKRPMEEV IKDHFKKVFV
     PSWFTVDLKS GMLQITLDES DFFSAWVSAK DAGFPNIQND TKINYGGMLL RALFEHWSRS
     FSDVDEESPT HRFNSVPGHT PLILCESTGR PIFRLMIRDA AHETESQMLS DFVPPWVLDV
     VERNQLPKFN KMPFFLLPHL SLGIKTPKKD RLSATEMLQV RKVMEHVYEK ILNVNDASYS
     ENGIPSAAQM LSPSLQANIE ERVELYCQDQ KLDPEMDLRT VKHFIWKQGG DLMLYYKPIR