ID   WDR48_CAEBR             Reviewed;         691 AA.
AC   A8XSW2;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 3.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=WD repeat-containing protein 48 homolog;
GN   Name=wdr-48; ORFNames=CBG18038;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Together with wdr-20, binds to and stimulates the activity of
CC       the deubiquitinating enzyme usp-46, leading to deubiquitination and
CC       stabilization of the glr-1 glutamate receptor. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with usp-46; the interaction increases the catalytic
CC       activity of usp-46 in the presence of wdr-20. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR48 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAP35565.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; HE600963; CAP35565.2; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; A8XSW2; -.
DR   SMR; A8XSW2; -.
DR   STRING; 6238.CBG18038; -.
DR   WormBase; CBG18038a; CBP37976; WBGene00037535; Cbr-wdr-48.
DR   eggNOG; KOG0308; Eukaryota.
DR   HOGENOM; CLU_014960_0_1_1; -.
DR   InParanoid; A8XSW2; -.
DR   OrthoDB; 261328at2759; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR   GO; GO:0016579; P:protein deubiquitination; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR021772; WDR48/Bun107.
DR   Pfam; PF11816; DUF3337; 1.
DR   Pfam; PF00400; WD40; 2.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..691
FT                   /note="WD repeat-containing protein 48 homolog"
FT                   /id="PRO_0000378974"
FT   REPEAT          27..82
FT                   /note="WD 1"
FT   REPEAT          88..130
FT                   /note="WD 2"
FT   REPEAT          133..168
FT                   /note="WD 3"
FT   REPEAT          180..219
FT                   /note="WD 4"
FT   REPEAT          222..261
FT                   /note="WD 5"
FT   REPEAT          264..303
FT                   /note="WD 6"
FT   REPEAT          306..347
FT                   /note="WD 7"
FT   REPEAT          399..438
FT                   /note="WD 8"
SQ   SEQUENCE   691 AA;  77852 MW;  5D051DC5CB3FD7EC CRC64;
     MSGASNTSQS GSKKKLSFII RDEQEPLHRS AVSALQYDAL HSRLFTGGSD TIIRTWSVPQ
     HKDAFSARGG VRSAGKNSPV QYQSSLERHT DWVTDMVLCG NGKLLVSSSN DTTVKVWSIE
     RDNKHGYLDS LNLHTDYVSC LAYAPLAEKV VSASFDRNIF VYDVNSNFNN FRVLVNNLLG
     CKNSIYSLAT TPNLSHCLFF SPHQQIRMFD PRTNDKPMKM RGHSDNVRAL LLNDDGTRAL
     SAGSDGTIRL WDIGMQKNIA TGIAHEEGVW TIQVDASFKF VYSGGRDRYV LKSPVNDLSK
     FQVLFKEEAP VKKLLLSEKE NPSSIWVGTW KSDIKRWSLN SANQNSNGGD EEGVSSFSTY
     YTTCKPRSSS PPPGITAPKH IQRLTDAREL QNTPELMISG APAINKYKIL NDKRHVLTSD
     TEDNVALYDV LAGKKVKEYG KRALENVFEE KSKTVYVPSW FIVDSKSGML QITLDELDVF
     SSWLTTKDAG FDDSDKETKV NYGGMMLRSL FERWPPCKLA TAEAGESDEV QKATSHYYTL
     PEHTPFIVCE GNGRPLFRLL VGDAGNEFES GELAQCVPPW VTDMIERNVL PKFNKMPFYL
     LPHPSTNSKQ PKKDRLSATE MLLVKKVMEH VYEKVLGNVD ANTVPLNQIH TKIEMYCNDQ
     KLEPETDLRT VKHFYWKQSG ELLLYYRPVK N