ID   WDR48_CULQU             Reviewed;         670 AA.
AC   B0X2V9;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=WD repeat-containing protein 48 homolog;
GN   ORFNames=CPIJ014111;
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB;
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of deubiquitinating complexes. Activates
CC       deubiquitination by increasing the catalytic turnover without
CC       increasing the affinity of deubiquitinating enzymes for the substrate
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR48 family. {ECO:0000305}.
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DR   EMBL; DS232301; EDS39433.1; -; Genomic_DNA.
DR   RefSeq; XP_001863981.1; XM_001863946.1.
DR   AlphaFoldDB; B0X2V9; -.
DR   SMR; B0X2V9; -.
DR   STRING; 7176.CPIJ014111-PA; -.
DR   GeneID; 6046856; -.
DR   KEGG; cqu:CpipJ_CPIJ014111; -.
DR   VEuPathDB; VectorBase:CPIJ014111; -.
DR   VEuPathDB; VectorBase:CQUJHB012534; -.
DR   eggNOG; KOG0308; Eukaryota.
DR   HOGENOM; CLU_014960_0_1_1; -.
DR   InParanoid; B0X2V9; -.
DR   OMA; NWFNVDL; -.
DR   OrthoDB; 261328at2759; -.
DR   PhylomeDB; B0X2V9; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR021772; WDR48/Bun107.
DR   Pfam; PF11816; DUF3337; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..670
FT                   /note="WD repeat-containing protein 48 homolog"
FT                   /id="PRO_0000378977"
FT   REPEAT          13..53
FT                   /note="WD 1"
FT   REPEAT          59..98
FT                   /note="WD 2"
FT   REPEAT          101..140
FT                   /note="WD 3"
FT   REPEAT          152..191
FT                   /note="WD 4"
FT   REPEAT          194..233
FT                   /note="WD 5"
FT   REPEAT          236..275
FT                   /note="WD 6"
FT   REPEAT          278..328
FT                   /note="WD 7"
FT   REPEAT          359..398
FT                   /note="WD 8"
FT   REGION          321..348
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          613..645
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        321..347
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        619..642
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   670 AA;  73405 MW;  CF787A0983E9ED3B CRC64;
     MVSFVIRDAE EKRHRNGVNA LQLDPVNGRL YSAGRDAIIR VWNSTQTSSQ EPYIQSMEHH
     NDWVNDIVLC CGGRNLISAS CDTTVKVWNA HKGFCMSTLR THRDYVQALA YAKDREQVAS
     AGLDKAIFLW DVNTLTALTA SNNTVTTSSI TGSKDSIYSL AMNPSGTIIV SGSTENTLRI
     WDPRTCNKIA KLKGHTENVK ALVVSEDGTQ VVSGSSDGKI KLWSIGQQRC IQTISVHSEG
     VWALLMTDNF SHVISGSRDK KIVMTELRNP TNSVLICEER APVLSLCYNI DQTGIWATTW
     NSDVRCWKLN KTDKLSNYSY SSNSSINSGG GGDGTPVTNS ASNATPASAG KGYEVACIKG
     GAAIKKYHVL NDKRFMLTKD SEQNVAIYDV LKVKKVEDLG KVDYEEEIKK RSQRVHVPNW
     FTVDLKTGMP TIVLGQDEVD CFAAWVSAEA GLPEHAESGS DPKVNYGSLL LQALLEYWKP
     PPPHHHLQGG VPDMENGCDG DIRGNEYFIV PKHTPIIFSE VGGRNVCRLL VKDAAGETES
     ALLSETVPSW VTNVVIERTI PKFIKLPFYL LAHPSMLKQD RSKKERLIAN EFIQCRKVCE
     HVLEKVLGAD LPGGGGGSST GGGGNSNSSQ NNSQSDANSE GSQVPAEERI ELLCNDVNNE
     DYGKNIHLNT