WDR48_DICDI
ID WDR48_DICDI Reviewed; 1172 AA.
AC Q54ZP5; Q76NV2;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=WD repeat-containing protein 48 homolog;
GN ORFNames=DDB_G0277533;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SIMILARITY: Belongs to the WD repeat WDR48 family. {ECO:0000305}.
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DR EMBL; AAFI02000020; EAL68729.1; -; Genomic_DNA.
DR RefSeq; XP_642597.1; XM_637505.1.
DR AlphaFoldDB; Q54ZP5; -.
DR SMR; Q54ZP5; -.
DR STRING; 44689.DDB0237514; -.
DR PaxDb; Q54ZP5; -.
DR EnsemblProtists; EAL68729; EAL68729; DDB_G0277533.
DR GeneID; 8621014; -.
DR KEGG; ddi:DDB_G0277533; -.
DR dictyBase; DDB_G0277533; -.
DR eggNOG; KOG0308; Eukaryota.
DR HOGENOM; CLU_274005_0_0_1; -.
DR InParanoid; Q54ZP5; -.
DR OMA; TKANDSM; -.
DR Reactome; R-DDI-110314; Recognition of DNA damage by PCNA-containing replication complex.
DR Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR PRO; PR:Q54ZP5; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0016579; P:protein deubiquitination; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR021772; WDR48/Bun107.
DR Pfam; PF11816; DUF3337; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..1172
FT /note="WD repeat-containing protein 48 homolog"
FT /id="PRO_0000378989"
FT REPEAT 152..202
FT /note="WD 1"
FT REPEAT 208..246
FT /note="WD 2"
FT REPEAT 249..548
FT /note="WD 3"
FT REPEAT 560..599
FT /note="WD 4"
FT REPEAT 602..641
FT /note="WD 5"
FT REPEAT 645..683
FT /note="WD 6"
FT REPEAT 686..727
FT /note="WD 7"
FT REPEAT 794..833
FT /note="WD 8"
FT REGION 1..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 745..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 926..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..502
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..544
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1172 AA; 132138 MW; E259DEFC1C5C23FF CRC64;
MYEYYSTGKI RSLPQQVDSN GINSKPMNSS PSTPIPNNNN NNNNNNNNNN NNNNNNNNNN
NNNRNKSQQS FYLNNNNRNC GFSSPTKPQY NNNNNNNNNN NSNYNHSYGG GGGGTTSQFQ
QHHLHPVNRK PPKFKISYSV KNTLNNTIIP DRHCFGVNSL AYNHRKSILY SAGRDSTIKS
YQIGGGDNDN DINEKNEYGF KFKKSFNDHT DWVNDLFFND SNILVSCSSD STIKIWNTDS
ERCVNSLKFH DDYVKVLAYA PKANYFASSG LDSHIKIWDL SICSISQSFS IDNNNNNNHN
SSSNYNQFGD TSILKHITNN SQPTNKINNC NINVVNGNIN ISTNNNNNNS SSSNNNNNNN
NNNNNGQTNT HENTAETSDS EGSKDDNQLS SVNKNGIRSN LSNNNFRNID NIDEYTPPSS
VLNHTPKILS SNGRNVNNRE NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNINNNNHE
NNGNVDVDDE DDDDDDDDDD DDDCNKNKKK YDDNNNNNNY NNNNNKKNNS NDNNNDNNNL
NKKFSPMFGS GSYLVGKSGG EGISIYSLAI AQDASFVVSG STERAIRGWD VRSGQKIFKL
KGHTDNIRSI LLNDNSTRCL SASSDGTVRL WDIGEQRCIQ VFDDLHTDSV WTLATNDSFS
HFFSGGRDGM IFLTDLKTHQ SRLVSRENEP ILKILNNQDD QSIWVSTTSS TIKNYGLSNF
YDKNQSIDNN TTNCGSISSE ILYNNNNNNN NNNNNNNNNN NNNNNNNNNN REKLSTINED
SNGLQVDEPK IKIQGRAGII KNQVLNNRRQ VLTKDNDNNV QLWDITKGKE IESFGKVDFD
KKLEEFNEVI SIPKWFQVDC KTGSLFISLE SPLCFSADAY QTNLGLTPTE DSLINIGESI
LYSLFSKWIM GYNLIQLNAT TNKDNELNHS NDSVNSSLSS NTSGDNNNNN YNNYNNYNNN
NNNGLQKSSS SSSIVSTNST TPNSGRPLIE IMAKKSIFHL PSNTDVVISD ETSGLVLYRS
RIEEFTGREQ IKIIDWLYNC LETSAIPIKR DNQKISFSVE VNEKIPQNLN APYYIQVRKI
CDHVLNNFFI NPNNNNNNNS SVNNDLPKGE EFFEICLQNK ILLPHYTLGT VKSFFWKQNS
TIPLTARVKA QYINETELVK YLKQLSLNHN KK
