ID   WDR48_DROAN             Reviewed;         667 AA.
AC   B3MET8;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=WD repeat-containing protein 48 homolog;
GN   ORFNames=GF12420;
OS   Drosophila ananassae (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7217;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14024-0371.13;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Regulator of deubiquitinating complexes. Activates
CC       deubiquitination by increasing the catalytic turnover without
CC       increasing the affinity of deubiquitinating enzymes for the substrate
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR48 family. {ECO:0000305}.
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DR   EMBL; CH902619; EDV35552.1; -; Genomic_DNA.
DR   RefSeq; XP_001958730.2; XM_001958694.2.
DR   AlphaFoldDB; B3MET8; -.
DR   SMR; B3MET8; -.
DR   STRING; 7217.FBpp0115612; -.
DR   EnsemblMetazoa; FBtr0117120; FBpp0115612; FBgn0089457.
DR   GeneID; 6495270; -.
DR   KEGG; dan:6495270; -.
DR   eggNOG; KOG0308; Eukaryota.
DR   HOGENOM; CLU_014960_0_1_1; -.
DR   InParanoid; B3MET8; -.
DR   OMA; NWFNVDL; -.
DR   OrthoDB; 261328at2759; -.
DR   PhylomeDB; B3MET8; -.
DR   Proteomes; UP000007801; Unassembled WGS sequence.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR021772; WDR48/Bun107.
DR   Pfam; PF11816; DUF3337; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..667
FT                   /note="WD repeat-containing protein 48 homolog"
FT                   /id="PRO_0000378978"
FT   REPEAT          26..65
FT                   /note="WD 1"
FT   REPEAT          71..110
FT                   /note="WD 2"
FT   REPEAT          113..152
FT                   /note="WD 3"
FT   REPEAT          164..203
FT                   /note="WD 4"
FT   REPEAT          206..245
FT                   /note="WD 5"
FT   REPEAT          248..287
FT                   /note="WD 6"
FT   REPEAT          290..331
FT                   /note="WD 7"
FT   REPEAT          350..389
FT                   /note="WD 8"
FT   REGION          591..615
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   667 AA;  75209 MW;  841DC1AAAC135805 CRC64;
     MLTHKTCQAR KKMQVSFVIR DAEEKQHRNG VNALQLDANN GKLYSAGRDA IIRVWNTRTE
     SNEKYIQSME HHNDWVNDIV LCCNGRNLIS ASCDTTVKVW NAQKGFCMST LRTHRDYVQA
     LAYAKDREQV ASAGLDKAIF LWDVNTLTAL TASNNTVTTS SLTGSKDSIY SLAMNPSGTV
     IVSGSTENIL RIWDPRTCMR SMKLRGHTEN VRCLVVSPDG NQVVSGSSDG TIKVWNLGQQ
     RCVQTIHVHK EGVWSLLMSE NFQYIISGSR DRNIIVTEMR NPSNKMLVCE EQAPVLSLGY
     NIDKTGVWAT TWNSDIRCWK LPMYDRCTLN SSGGLDAQWT QGGTELACIK GGAAIKECTV
     LNDKRYIITK DSQDQVVVYD VLRVVKKEQL GAVDYEAEVK KRNKQVYIPN WFTVDLKTGM
     PTIVLGQEEV DCFAAWVSIE AGLPECVDPT TEIKINYGKL LLEALLEHWT PHNMPPNDMD
     QDMHGNGYFQ VPKHTPVIFS EVGGRTVCRL LVRDAAGDSE STLLQETAPQ WVTDVVIEKN
     IPKFLKIPFF LQPHPQMTKP ERTKKDRLVA NEFIQCRKVC EHVLEKVLNA ETTPSGGNAN
     NSLQNSQSDA NSEGSQLPAE ERIELWCNDV VVDPNMDLRT VRHFIWKQST DLTFQYKTKQ
     NFNYDGK