ID   WDR48_DROGR             Reviewed;         667 AA.
AC   B4J8H6;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=WD repeat-containing protein 48 homolog;
GN   ORFNames=GH21936;
OS   Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Regulator of deubiquitinating complexes. Activates
CC       deubiquitination by increasing the catalytic turnover without
CC       increasing the affinity of deubiquitinating enzymes for the substrate
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR48 family. {ECO:0000305}.
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DR   EMBL; CH916367; EDW02335.1; -; Genomic_DNA.
DR   RefSeq; XP_001987468.1; XM_001987432.1.
DR   AlphaFoldDB; B4J8H6; -.
DR   SMR; B4J8H6; -.
DR   STRING; 7222.FBpp0155842; -.
DR   EnsemblMetazoa; FBtr0468213; FBpp0418351; FBgn0129397.
DR   GeneID; 6560409; -.
DR   KEGG; dgr:6560409; -.
DR   eggNOG; KOG0308; Eukaryota.
DR   HOGENOM; CLU_014960_0_1_1; -.
DR   InParanoid; B4J8H6; -.
DR   OMA; NWFNVDL; -.
DR   OrthoDB; 261328at2759; -.
DR   PhylomeDB; B4J8H6; -.
DR   Proteomes; UP000001070; Unassembled WGS sequence.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR021772; WDR48/Bun107.
DR   Pfam; PF11816; DUF3337; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..667
FT                   /note="WD repeat-containing protein 48 homolog"
FT                   /id="PRO_0000378980"
FT   REPEAT          26..65
FT                   /note="WD 1"
FT   REPEAT          71..110
FT                   /note="WD 2"
FT   REPEAT          113..152
FT                   /note="WD 3"
FT   REPEAT          164..203
FT                   /note="WD 4"
FT   REPEAT          206..245
FT                   /note="WD 5"
FT   REPEAT          248..287
FT                   /note="WD 6"
FT   REPEAT          290..330
FT                   /note="WD 7"
FT   REPEAT          349..388
FT                   /note="WD 8"
FT   REGION          591..615
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   667 AA;  75432 MW;  FD4D00EBE13C5AA7 CRC64;
     MLTHKTCQAR KKMQVSFVIR DAEEKQHRNG VNALQLDPNN GKLYSAGRDA IIRVWNTRTE
     SNEKYIQSME HHNDWVNDIV LCCNGRNLIS ASCDTTVKVW NAHKGFCMST LRTHRDYVQA
     LAYAKDREQV ASAGLDKAIF LWDVNTLTAL TASNNTVTTS SLTGSKDSIY SLAMNPSGTV
     IVSGSTENIL RIWDPRTCMR SMKLRGHTEN VRCLVVSPDG NQVVSGSSDG TIKVWNLGQQ
     RCIQTIHVHK EGVWSLLMSE NFQYIISGSR DRNIIVTEIR NPSNKMLVCE EKAPVLSLGY
     NIDKTGVWAT TWNSDIRCWK LPMYDRCILT SGGMDAQWTL GGTEMACIRG GAAIKECTVL
     NDKRYIITKD SQDKVVVYDV LRVIKKEELG PIEYEKEVMK RNKQVYIPNW FTVDLKTGMP
     TIVLGQEEVD CFSAWVSIEA GLPECDDPTT EIKINYGKLL LEALLEYWTP PHSIPPNEME
     PDVRGNGYFQ VPKHTPVIFS EVGGRTVCRL LVRDAAGDSE STLLHETAPQ WVTDVVIERN
     IPKFLKIPFF LQPHPQMTKP ERSKKDRLVA NEFIQCRKVC EHVLEKVLNT ETTPSGGNAN
     NSLQNSQSDA NSEGSQLPAE ERIELWCNDV VVDPNMDLRT VRHFIWKQST DLTFQYKAKQ
     NFNFDGK