WDR48_DROME
ID WDR48_DROME Reviewed; 668 AA.
AC Q1LZ08; Q8IGK7;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=WD repeat-containing protein 48 homolog;
GN ORFNames=CG9062;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulator of deubiquitinating complexes. Activates
CC deubiquitination by increasing the catalytic turnover without
CC increasing the affinity of deubiquitinating enzymes for the substrate
CC (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR48 family. {ECO:0000305}.
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DR EMBL; AE013599; AAM68723.1; -; Genomic_DNA.
DR EMBL; BT001736; AAN71491.1; -; mRNA.
DR EMBL; BT025218; ABF17909.1; -; mRNA.
DR RefSeq; NP_725018.1; NM_165814.3.
DR AlphaFoldDB; Q1LZ08; -.
DR SMR; Q1LZ08; -.
DR BioGRID; 61994; 1.
DR STRING; 7227.FBpp0304695; -.
DR PaxDb; Q1LZ08; -.
DR PRIDE; Q1LZ08; -.
DR DNASU; 36199; -.
DR EnsemblMetazoa; FBtr0088181; FBpp0087277; FBgn0033607.
DR GeneID; 36199; -.
DR KEGG; dme:Dmel_CG9062; -.
DR UCSC; CG9062-RB; d. melanogaster.
DR FlyBase; FBgn0033607; CG9062.
DR VEuPathDB; VectorBase:FBgn0033607; -.
DR eggNOG; KOG0308; Eukaryota.
DR GeneTree; ENSGT00920000149157; -.
DR HOGENOM; CLU_014960_0_1_1; -.
DR InParanoid; Q1LZ08; -.
DR OMA; NWFNVDL; -.
DR OrthoDB; 261328at2759; -.
DR PhylomeDB; Q1LZ08; -.
DR Reactome; R-DME-110314; Recognition of DNA damage by PCNA-containing replication complex.
DR Reactome; R-DME-5689880; Ub-specific processing proteases.
DR BioGRID-ORCS; 36199; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 36199; -.
DR PRO; PR:Q1LZ08; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0033607; Expressed in egg cell and 21 other tissues.
DR ExpressionAtlas; Q1LZ08; baseline and differential.
DR Genevisible; Q1LZ08; DM.
DR GO; GO:0005634; C:nucleus; ISS:FlyBase.
DR GO; GO:0043130; F:ubiquitin binding; ISS:FlyBase.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0016579; P:protein deubiquitination; ISS:FlyBase.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR021772; WDR48/Bun107.
DR Pfam; PF11816; DUF3337; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT CHAIN 1..668
FT /note="WD repeat-containing protein 48 homolog"
FT /id="PRO_0000378981"
FT REPEAT 26..65
FT /note="WD 1"
FT REPEAT 71..110
FT /note="WD 2"
FT REPEAT 113..152
FT /note="WD 3"
FT REPEAT 164..203
FT /note="WD 4"
FT REPEAT 206..245
FT /note="WD 5"
FT REPEAT 248..287
FT /note="WD 6"
FT REPEAT 290..331
FT /note="WD 7"
FT REPEAT 350..389
FT /note="WD 8"
FT REGION 592..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 354
FT /note="A -> T (in Ref. 3; AAN71491)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 668 AA; 75266 MW; A847EDF5C99914B8 CRC64;
MLTHKTCQAR KKMQVSFVIR DAEEKQHRNG VNALQLDANN GKLYSAGRDA IIRVWNTRTD
SSEKYIQSME HHNDWVNDIV LCCNGRNLIS ASCDTTVKVW NAQKGFCMST LRTHRDYVQA
LAYAKDREQV ASAGLDKAIF LWDVNTLTAL TASNNTVTTS SLTGSKDSIY SLAMNPSGTV
IVSGSTENIL RIWDPRTCMR RMKLRGHTEN VRCLVVSPDG NQVVSGSSDG TIKVWNLGQQ
RCVQTIHVHK EGVWSLLMSE NFQYIISGSR DRNIIVTEMR NPSNKTLVCE EQAPVLSLGY
NIDKTGVWAT TWNSDIRCWK LPMYDRCTLN SSGGMDAQWT QGGTEVACIK GGAAIKECAV
LNDKRYIITK DSQDQVVVYD VLRVVKKEQL GAVDFEAEVK KRNKQVYIPN WFTVDLKTGM
PTIVLGQEEV DCFSAWVSIE AGLPECVDPT TEIKINYGKL LLEALLEYWT PPHSIPPNEM
EPDMHGNGYF QVPKHTPVIF SEVGGRTVCR LLVRDAAGDS ESTLLHETAP QWVTDVVIEK
NIPKFLKIPF FLQPHPQMTK PERTKKDRLV ANEFIQCRKV CEHVLEKVLN AETTPSGGNA
NNSLQNSQSD ANSEGSQLPA EERIELWCND VVVDPNMDLR TVRHFIWKQS TDLTFQYKTK
QNFNYDGK
