ID   WDR48_DROMO             Reviewed;         679 AA.
AC   B4KRQ4;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=WD repeat-containing protein 48 homolog;
GN   ORFNames=GI19644;
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Regulator of deubiquitinating complexes. Activates
CC       deubiquitination by increasing the catalytic turnover without
CC       increasing the affinity of deubiquitinating enzymes for the substrate
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR48 family. {ECO:0000305}.
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DR   EMBL; CH933808; EDW08324.1; -; Genomic_DNA.
DR   RefSeq; XP_002004389.1; XM_002004353.2.
DR   AlphaFoldDB; B4KRQ4; -.
DR   SMR; B4KRQ4; -.
DR   STRING; 7230.FBpp0168861; -.
DR   EnsemblMetazoa; FBtr0170369; FBpp0168861; FBgn0142381.
DR   GeneID; 6578478; -.
DR   KEGG; dmo:Dmoj_GI19644; -.
DR   eggNOG; KOG0308; Eukaryota.
DR   HOGENOM; CLU_014960_0_1_1; -.
DR   InParanoid; B4KRQ4; -.
DR   OMA; NWFNVDL; -.
DR   OrthoDB; 261328at2759; -.
DR   PhylomeDB; B4KRQ4; -.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR021772; WDR48/Bun107.
DR   Pfam; PF11816; DUF3337; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..679
FT                   /note="WD repeat-containing protein 48 homolog"
FT                   /id="PRO_0000378982"
FT   REPEAT          26..65
FT                   /note="WD 1"
FT   REPEAT          71..110
FT                   /note="WD 2"
FT   REPEAT          113..152
FT                   /note="WD 3"
FT   REPEAT          164..203
FT                   /note="WD 4"
FT   REPEAT          206..245
FT                   /note="WD 5"
FT   REPEAT          248..287
FT                   /note="WD 6"
FT   REPEAT          290..330
FT                   /note="WD 7"
FT   REPEAT          349..388
FT                   /note="WD 8"
FT   REGION          594..615
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   679 AA;  76731 MW;  88CCAE015E04E1F5 CRC64;
     MLTHKTCQAR KKMQVSFVIR DAEEKQHRNG VNALQLDSNN GKLYSAGRDA IIRVWNTRTE
     ANEKYIQSME HHNDWVNDIV LCCNGRNLIS ASCDTTVKVW NAHKGFCMST LRTHRDYVQA
     LAYAKDREQV ASAGLDKAIF LWDVNTLTAL TASNNTVTTS SLTGSKDSIY SLAMNPSGTV
     IVSGSTENIL RIWDPRTCMR SMKLRGHTEN VRCLVVSPDG NQVVSGSSDG TIKVWNLGQQ
     RCIQTIHVHK EGVWSLLMSE NFQYIISGSR DRNIIVTEMR NPSNKMLVCE EKAPVLSLGY
     NIDKTGVWAT TWNSDIRCWK LPMYDRCVLS SGGMDAQWTL GGTELACIKG GAAIKECTVL
     NDKRYIITKD SQDQVVVYDV LRVTKKEELG VVDYEEEVKK RNKQVYIPNW FTVDLKTGMP
     TIVLGQEEVD CFAAWVSIEA GLPECDDPTT EIKINYGKLL LEALLEYWTP PHSMPPNEME
     PDVRGNGYFQ VPKHTPVIFS EVGGRTVCRL LVRDAAGDSE STLLHETAPQ WVTDVVIERN
     IPKFLKIPFF LQPHPQMTKP ERTKKDRLVA NEFIQCRKVC EHVLEKVLNA ETTPSAGNAN
     NSLQNSQSDA NSEGSQLPAE ERIELWCNDV IVDPNMDLRT VRHFIWKQST DLTFQYKTKQ
     NFNFDGSIGD SLERVTRKY