ID   WDR48_DROPS             Reviewed;         680 AA.
AC   Q28YY2;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 2.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=WD repeat-containing protein 48 homolog;
GN   ORFNames=GA21511;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Regulator of deubiquitinating complexes. Activates
CC       deubiquitination by increasing the catalytic turnover without
CC       increasing the affinity of deubiquitinating enzymes for the substrate
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR48 family. {ECO:0000305}.
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DR   EMBL; CM000071; EAL25833.2; -; Genomic_DNA.
DR   RefSeq; XP_001361255.2; XM_001361218.3.
DR   AlphaFoldDB; Q28YY2; -.
DR   SMR; Q28YY2; -.
DR   STRING; 7237.FBpp0276315; -.
DR   EnsemblMetazoa; FBtr0277877; FBpp0276315; FBgn0081497.
DR   GeneID; 4804743; -.
DR   KEGG; dpo:Dpse_GA21511; -.
DR   eggNOG; KOG0308; Eukaryota.
DR   HOGENOM; CLU_014960_0_1_1; -.
DR   InParanoid; Q28YY2; -.
DR   OMA; NWFNVDL; -.
DR   Proteomes; UP000001819; Chromosome 3.
DR   Bgee; FBgn0081497; Expressed in female reproductive system and 3 other tissues.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR021772; WDR48/Bun107.
DR   Pfam; PF11816; DUF3337; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..680
FT                   /note="WD repeat-containing protein 48 homolog"
FT                   /id="PRO_0000378984"
FT   REPEAT          26..65
FT                   /note="WD 1"
FT   REPEAT          71..110
FT                   /note="WD 2"
FT   REPEAT          113..152
FT                   /note="WD 3"
FT   REPEAT          164..203
FT                   /note="WD 4"
FT   REPEAT          206..245
FT                   /note="WD 5"
FT   REPEAT          248..287
FT                   /note="WD 6"
FT   REPEAT          290..331
FT                   /note="WD 7"
FT   REPEAT          350..389
FT                   /note="WD 8"
FT   REGION          594..618
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        594..616
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   680 AA;  76545 MW;  0F02B3D31A9D169B CRC64;
     MLTHKTCQAR KKMQVSFVIR DAEEKQHRNG VNSLQLDPNN GKLYSAGRDA IIRVWNTRSE
     SSEKYIQSME HHNDWVNDIV LCCNGRNLIS ASCDTTVKVW NAQKGFCMST LRTHRDYVQA
     LAYAKDREQV ASAGLDKAIF LWDVNTLTAL TASNNTVTTS SLTGSKDSIY SLAMNPSGTV
     IVSGSTENIL RIWDPRTCMR SMKLRGHTEN VRCLVVSPDG NQVVSGSSDG TIKVWNLGQQ
     RCVQTIHVHK EGVWSLLMSE NFQYIISGSR DQNIIVTEMR NPSNKTLVCE EKAPVLSLGY
     NMDKTGVWAT TWNSDIRCWK LPMYDRGTLN SSGGLDAQWT QGGTELACIK GGAAIKECTV
     LNDKRYILTK DSQDQVVLYD VLRVVKKDTL GPIDYEAEVK KRNKQVYIPN WFTVDLKTGM
     PTIVLGQEEV DCFSAWVSIE AGLPECVDPT TEIKINYGKL LLEALLEYWT PPHSIPQNEL
     EPDMHGNGYF QVPKHTPVIF SEVGGRTVCR LLVRDAAGDS ECTLLHETAP QWVTDVVIEK
     NIPKFLKIPF FLQPHPQMTK PERTKKDRLV ANEFIQCRKV CEHVLEKVLN AETTPSGANA
     NNSLQNSQSD GNSEGSQLPA EERIELSCND VVVDPNMDLR TVRHFIWKQS TDLTFQYKTK
     QNFNYDGSIG DSLERVTRKY