WDR48_DROSE
ID WDR48_DROSE Reviewed; 680 AA.
AC B4HND9;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=WD repeat-containing protein 48 homolog;
GN ORFNames=GM20456;
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rob3c / Tucson 14021-0248.25;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Regulator of deubiquitinating complexes. Activates
CC deubiquitination by increasing the catalytic turnover without
CC increasing the affinity of deubiquitinating enzymes for the substrate
CC (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR48 family. {ECO:0000305}.
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DR EMBL; CH480816; EDW47375.1; -; Genomic_DNA.
DR RefSeq; XP_002033362.1; XM_002033326.1.
DR AlphaFoldDB; B4HND9; -.
DR SMR; B4HND9; -.
DR STRING; 7238.B4HND9; -.
DR EnsemblMetazoa; FBtr0203441; FBpp0201933; FBgn0175338.
DR GeneID; 6608628; -.
DR KEGG; dse:6608628; -.
DR HOGENOM; CLU_014960_0_1_1; -.
DR OMA; NWFNVDL; -.
DR PhylomeDB; B4HND9; -.
DR Proteomes; UP000001292; Unassembled WGS sequence.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR021772; WDR48/Bun107.
DR Pfam; PF11816; DUF3337; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT CHAIN 1..680
FT /note="WD repeat-containing protein 48 homolog"
FT /id="PRO_0000378985"
FT REPEAT 26..65
FT /note="WD 1"
FT REPEAT 71..110
FT /note="WD 2"
FT REPEAT 113..152
FT /note="WD 3"
FT REPEAT 164..203
FT /note="WD 4"
FT REPEAT 206..245
FT /note="WD 5"
FT REPEAT 248..287
FT /note="WD 6"
FT REPEAT 290..331
FT /note="WD 7"
FT REPEAT 350..389
FT /note="WD 8"
FT REGION 592..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 680 AA; 76616 MW; 75F4D5F5DF8D26D6 CRC64;
MLTHKTCQAR KKMQVSFVIR DAEEKQHRNG VNALQLDANN GKLYSAGRDA IIRVWNTRTD
SSEKYIQSME HHNDWVNDIV LCCNGRNLIS ASCDTTVKVW NAQKGFCMST LRTHRDYVQA
LAYAKDREQV ASAGLDKAIF LWDVNTLTAL TASNNTVTTS SLTGSKDSIY SLAMNPSGTV
IVSGSTENIL RIWDPRTCMR IMKLRGHTEN VRCLVVSPDG NQVVSGSSDG TIKVWNLGQQ
RCVQTIHVHK EGVWSLLMSE NFQYIISGSR DRNIIVTEMR NPSNKTLVCE EQAPVLSLGY
NIDKTGVWAT TWNSDIRCWK LPMYDRCTLN SSGGMDAQWT QGGTEVACIK GGAAIKECAV
LNDKRYIITK DSQDQVVVYD VLRVVKKEQL GAVDYEAEVK KRNKQVYIPN WFTVDLKTGM
PTIVLGQEEV DCFSAWVSIE AGLPECVDPT TEIKINYGKL LLEALLEYWT PPHSIPPNEM
EPDMHGNGYF QVPKHTPVIF SEVGGRTVCR LLVRDAAGDS ESTLLHETAP QWVTDVVIEK
NIPKFLKIPF FLQPHPQMTK PERTKKDRLV ANEFIQCRKV CEHVLEKVLN AETTPSGGNA
NNSLQNSQSD ANSEGSQLPA EERIELWCND VVVDPNMDLR TVRHFIWKQS TDLTFQYKTK
QNFNYDGSIG DSLERVTRKY