ID   WDR48_DROSI             Reviewed;         668 AA.
AC   B4QB64;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=WD repeat-containing protein 48 homolog;
GN   ORFNames=GD25924;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Regulator of deubiquitinating complexes. Activates
CC       deubiquitination by increasing the catalytic turnover without
CC       increasing the affinity of deubiquitinating enzymes for the substrate
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR48 family. {ECO:0000305}.
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DR   EMBL; CM000362; EDX06597.1; -; Genomic_DNA.
DR   AlphaFoldDB; B4QB64; -.
DR   SMR; B4QB64; -.
DR   STRING; 7240.B4QB64; -.
DR   EnsemblMetazoa; FBtr0353321; FBpp0317815; FBgn0197202.
DR   HOGENOM; CLU_014960_0_1_1; -.
DR   OMA; NWFNVDL; -.
DR   PhylomeDB; B4QB64; -.
DR   Proteomes; UP000000304; Chromosome 2r.
DR   Bgee; FBgn0197202; Expressed in female reproductive system and 3 other tissues.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR021772; WDR48/Bun107.
DR   Pfam; PF11816; DUF3337; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..668
FT                   /note="WD repeat-containing protein 48 homolog"
FT                   /id="PRO_0000378986"
FT   REPEAT          26..65
FT                   /note="WD 1"
FT   REPEAT          71..110
FT                   /note="WD 2"
FT   REPEAT          113..152
FT                   /note="WD 3"
FT   REPEAT          164..203
FT                   /note="WD 4"
FT   REPEAT          206..245
FT                   /note="WD 5"
FT   REPEAT          248..287
FT                   /note="WD 6"
FT   REPEAT          290..331
FT                   /note="WD 7"
FT   REPEAT          350..389
FT                   /note="WD 8"
FT   REGION          592..616
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   668 AA;  75239 MW;  44AB5D257A32A2A4 CRC64;
     MLTHKTCQAR KKMQVSFVIR DAEEKQHRNG VNALQLDANN GKLYSAGRDA IIRVWNTRTD
     SSEKYIQSME HHNDWVNDIV LCCNGRNLIS ASCDTTVKVW NAQKGFCMST LRTHRDYVQA
     LAYAKDREQV ASAGLDKAIF LWDVNTLTAL TASNNTVTTS SLTGSKDSIY SLAMNPSGTV
     IVSGSTENIL RIWDPRTCMR IMKLRGHTEN VRCLVVSPDG NQVVSGSSDG TIKVWNLGQQ
     RCVQTIHVHK EGVWSLLMSE NFQYIISGSR DRNIIVTEMR NPSNKTLVCE EQAPVLSLGY
     NIDKTGVWAT TWNSDIRCWK LPMYDRCTLN SSGGMDAQWT QGGTEVACIK GGAAIKECAV
     LNDKRYIITK DSQDQVVVYD VLRVVKKEQL GAVDYEAEVK KRNKQVYIPN WFTVDLKTGM
     PTIVLGQEEV DCFSAWVSIE AGLPECVDPT TEIKINYGKL LLEALLEYWT PPHSIPPNEM
     EPDMHGNGYF QVPKHTPVIF SEVGGRTVCR LLVRDAAGDS ESTLLHETAP QWVTDVVIEK
     NIPKFLKIPF FLQPHPQMTK PERTKKDRLV ANEFIQCRKV CEHVLEKVLN AETTPSGGNA
     NNSLQNSQSD ANSEGSQLPA EERIELWCND VVVDPNMDLR TVRHFIWKQS TDLTFQYKTK
     QNFNYDGK