ID   WDR48_DROVI             Reviewed;         667 AA.
AC   B4MFM2;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=WD repeat-containing protein 48 homolog;
GN   ORFNames=GJ15009;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Regulator of deubiquitinating complexes. Activates
CC       deubiquitination by increasing the catalytic turnover without
CC       increasing the affinity of deubiquitinating enzymes for the substrate
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR48 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH940667; EDW57193.1; -; Genomic_DNA.
DR   RefSeq; XP_002059856.2; XM_002059820.2.
DR   AlphaFoldDB; B4MFM2; -.
DR   SMR; B4MFM2; -.
DR   STRING; 7244.FBpp0229426; -.
DR   EnsemblMetazoa; FBtr0230934; FBpp0229426; FBgn0202209.
DR   GeneID; 6636494; -.
DR   KEGG; dvi:6636494; -.
DR   eggNOG; KOG0308; Eukaryota.
DR   HOGENOM; CLU_014960_0_1_1; -.
DR   InParanoid; B4MFM2; -.
DR   OMA; NWFNVDL; -.
DR   OrthoDB; 261328at2759; -.
DR   PhylomeDB; B4MFM2; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR021772; WDR48/Bun107.
DR   Pfam; PF11816; DUF3337; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..667
FT                   /note="WD repeat-containing protein 48 homolog"
FT                   /id="PRO_0000378987"
FT   REPEAT          26..65
FT                   /note="WD 1"
FT   REPEAT          71..110
FT                   /note="WD 2"
FT   REPEAT          113..152
FT                   /note="WD 3"
FT   REPEAT          164..203
FT                   /note="WD 4"
FT   REPEAT          206..245
FT                   /note="WD 5"
FT   REPEAT          248..287
FT                   /note="WD 6"
FT   REPEAT          290..330
FT                   /note="WD 7"
FT   REPEAT          349..388
FT                   /note="WD 8"
FT   REGION          591..615
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   667 AA;  75372 MW;  EC626BECEF1D7CFB CRC64;
     MLTHKTCQAR KKMQVSFVIR DAEEKQHRNG VNALQLDSNN GKLYSAGRDA IIRVWNTRTE
     SNDKYIQSME HHNDWVNDIV LCCNGRNLIS ASCDTTVKVW NAHKGFCMST LRTHRDYVQA
     LAYAKDREQV ASAGLDKAIF LWDVNTLTAL TASNNTVTTS SLTGSKDSIY SLAMNPSGTV
     IVSGSTENIL RIWDPRTCMR SMKLRGHTEN VRCLVVSPDG NQVVSGSSDG TIKVWNLGQQ
     RCIQTIHVHK EGVWSLLMSE NFQYIISGSR DRNIIVTEMR NPSNKMLVCE EKAPVLSLGY
     NIDKTGVWAT TWNSDIRCWK LPMYDRCTLS SGGMDAQWTM GGTELACIKG GAAIKECTVL
     NDKRYIITKD SQDQVVVYDV LRVIKKEELG PVDYEEEVKK RNKQVYIPNW FTVDLKTGMP
     TIVLGQEEVD CFAAWVSIEA GLPECDDPTT EIKINYGKLL LEALLEYWTP PHSMPPNEME
     PDVRGNGYFQ VPKHTPVIFS EVGGRTVCRL LVRDAAGDSE STLLHETAPQ WVTDVVIERN
     IPKFLKIPFF LQPHPQMTKP ERTKKDRLVA NEFIQCRKVC EHVLEKVLNA ETTPSGGNAN
     NSLQNSQSDA NSEGSQLPAE ERIELWCNDV IVDPNMDLRT VRHFIWKQST DLTFQYKTKQ
     NFNFDGK