ID   WDR4_CAEBR              Reviewed;         379 AA.
AC   A8XPH5;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit {ECO:0000255|HAMAP-Rule:MF_03056};
DE   AltName: Full=WD repeat-containing protein 4 homolog {ECO:0000255|HAMAP-Rule:MF_03056};
GN   Name=wdr-4 {ECO:0000312|WormBase:CBG16565};
GN   ORFNames=CBG16565 {ECO:0000312|WormBase:CBG16565};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Required for the formation of N(7)-methylguanine at position
CC       46 (m7G46) in tRNA. In the complex, it is required to stabilize and
CC       induce conformational changes of the catalytic subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_03056}.
CC   -!- PATHWAY: tRNA modification; N(7)-methylguanine-tRNA biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03056}.
CC   -!- SUBUNIT: Forms a heterodimer with the catalytic subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_03056}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03056}.
CC   -!- SIMILARITY: Belongs to the WD repeat TRM82 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03056}.
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DR   EMBL; HE600949; CAP34496.1; -; Genomic_DNA.
DR   RefSeq; XP_002641879.1; XM_002641833.1.
DR   AlphaFoldDB; A8XPH5; -.
DR   SMR; A8XPH5; -.
DR   STRING; 6238.CBG16565; -.
DR   EnsemblMetazoa; CBG16565.1; CBG16565.1; WBGene00036467.
DR   GeneID; 8583873; -.
DR   KEGG; cbr:CBG_16565; -.
DR   CTD; 8583873; -.
DR   WormBase; CBG16565; CBP18778; WBGene00036467; Cbr-wdr-4.
DR   eggNOG; KOG3914; Eukaryota.
DR   HOGENOM; CLU_706432_0_0_1; -.
DR   InParanoid; A8XPH5; -.
DR   OMA; VIFEHCK; -.
DR   OrthoDB; 937275at2759; -.
DR   UniPathway; UPA00989; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0043527; C:tRNA methyltransferase complex; IBA:GO_Central.
DR   GO; GO:0106004; P:tRNA (guanine-N7)-methylation; IEA:GOC.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03056; TRM82; 1.
DR   InterPro; IPR028884; Trm82.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR16288; PTHR16288; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; tRNA processing; WD repeat.
FT   CHAIN           1..379
FT                   /note="tRNA (guanine-N(7)-)-methyltransferase non-catalytic
FT                   subunit"
FT                   /id="PRO_0000370536"
FT   REPEAT          58..102
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          112..151
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          153..194
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          196..234
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   379 AA;  42655 MW;  047467DA1141D2DE CRC64;
     MSFITAFGDR VFVASGDLIR TFRIGDDEGM TPLISWSELN PERIQKPSFE AEKDLKAVDK
     RVILCLAHSN MIAAHGRRLV AVGTNEKQIH VFEYFIDNNY KIVKAEHIVT SVVPKAPTAI
     VFDREDAYVV VGDRSGDVHR FSVLNGSAIE MAGAISMILD VAFSPDGKRL LMADRDEKVR
     AMRYPSTYVI DAYCLGHTEY VKTLAIQDND TVWSSGGDKN LHMWSITNCS KPRRTIDLSE
     WDAPVRKISI NVAHKKIAVL FEKKDKMIVV DLETDPAATQ SVTILNESEC LDVTSTGHYF
     IVLGRSTITV INLLTMLQAT FPIDDELNAV LSATKDAVDN LFKNVTHNNQ LEYEKRKAEK
     FEQIEQKRRR LNNQEPSTS