ID   WDR4_CAEEL              Reviewed;         388 AA.
AC   Q23232;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 154.
DE   RecName: Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit {ECO:0000255|HAMAP-Rule:MF_03056};
DE   AltName: Full=WD repeat-containing protein 4 homolog {ECO:0000255|HAMAP-Rule:MF_03056};
GN   Name=wdr-4 {ECO:0000312|WormBase:Y102E9.2a};
GN   ORFNames=Y102E9.2 {ECO:0000312|WormBase:Y102E9.2a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Required for the formation of N(7)-methylguanine at position
CC       46 (m7G46) in tRNA. In the complex, it is required to stabilize and
CC       induce conformational changes of the catalytic subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_03056}.
CC   -!- PATHWAY: tRNA modification; N(7)-methylguanine-tRNA biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03056}.
CC   -!- SUBUNIT: Forms a heterodimer with the catalytic subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_03056}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03056}.
CC   -!- SIMILARITY: Belongs to the WD repeat TRM82 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03056}.
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DR   EMBL; FO081313; CCD70714.1; -; Genomic_DNA.
DR   PIR; T26372; T26372.
DR   RefSeq; NP_498476.1; NM_066075.4.
DR   AlphaFoldDB; Q23232; -.
DR   SMR; Q23232; -.
DR   BioGRID; 55430; 2.
DR   DIP; DIP-26730N; -.
DR   IntAct; Q23232; 1.
DR   STRING; 6239.Y102E9.2b; -.
DR   EPD; Q23232; -.
DR   PaxDb; Q23232; -.
DR   PeptideAtlas; Q23232; -.
DR   EnsemblMetazoa; Y102E9.2a.1; Y102E9.2a.1; WBGene00022420.
DR   GeneID; 190860; -.
DR   UCSC; Y102E9.2b; c. elegans.
DR   CTD; 190860; -.
DR   WormBase; Y102E9.2a; CE07574; WBGene00022420; wdr-4.
DR   eggNOG; KOG3914; Eukaryota.
DR   GeneTree; ENSGT00390000012174; -.
DR   InParanoid; Q23232; -.
DR   UniPathway; UPA00989; -.
DR   PRO; PR:Q23232; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00022420; Expressed in germ line (C elegans) and 4 other tissues.
DR   ExpressionAtlas; Q23232; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0043527; C:tRNA methyltransferase complex; IBA:GO_Central.
DR   GO; GO:0106004; P:tRNA (guanine-N7)-methylation; IEA:GOC.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03056; TRM82; 1.
DR   InterPro; IPR028884; Trm82.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR16288; PTHR16288; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; tRNA processing; WD repeat.
FT   CHAIN           1..388
FT                   /note="tRNA (guanine-N(7)-)-methyltransferase non-catalytic
FT                   subunit"
FT                   /id="PRO_0000370537"
FT   REPEAT          58..102
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          112..151
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          153..194
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          196..234
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REGION          365..388
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   388 AA;  43639 MW;  A2A9D378968C6750 CRC64;
     MSFITAFRER VFIASGDLIR TFRISEETEL KNFISWSKIN PERIQKPSFD IEKELKAVEK
     RVILCLAHSN VLTTHGRRLV AVGTNEKQIH VFEYFVNDKG DIVTAEHIVT SVVPKAPTAI
     VFDKEDAYVV VGDRAGDVHR FSVLNGSAIE MAGAISMILD VAFSPDGKRL LMADRDEKVR
     ALRYPATSVI DSFFLGHTEY VKTLAVQDND SLWSSGGDKN LYNWSIAKCS APRRTLDLSQ
     FDAPIRKISI NLQHKKIAVI FEKIETVVIV DLNQESLQTT SVSIVGESQC LDIASTKDYF
     AVLGRSTVHL IDLNNMEQKF VPIDEELTIT LTSTNDAIDN LFKNVTHNNQ QEYEKRKADK
     FEQIEKKKRR LNEDINGDDG EGPGPSNS