ID   WDR53_BOVIN             Reviewed;         358 AA.
AC   Q32KQ2;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=WD repeat-containing protein 53;
GN   Name=WDR53;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR53 family. {ECO:0000305}.
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DR   EMBL; BC109979; AAI09980.1; -; mRNA.
DR   RefSeq; NP_001069240.1; NM_001075772.2.
DR   AlphaFoldDB; Q32KQ2; -.
DR   SMR; Q32KQ2; -.
DR   STRING; 9913.ENSBTAP00000019520; -.
DR   PRIDE; Q32KQ2; -.
DR   Ensembl; ENSBTAT00000019520; ENSBTAP00000019520; ENSBTAG00000014660.
DR   GeneID; 518441; -.
DR   KEGG; bta:518441; -.
DR   CTD; 348793; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014660; -.
DR   VGNC; VGNC:56335; WDR53.
DR   eggNOG; ENOG502QQ86; Eukaryota.
DR   GeneTree; ENSGT00390000011073; -.
DR   InParanoid; Q32KQ2; -.
DR   OMA; EINCLSV; -.
DR   OrthoDB; 1551636at2759; -.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000014660; Expressed in semen and 104 other tissues.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR042453; WDR53.
DR   PANTHER; PTHR44666; PTHR44666; 1.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..358
FT                   /note="WD repeat-containing protein 53"
FT                   /id="PRO_0000328053"
FT   REPEAT          8..46
FT                   /note="WD 1"
FT   REPEAT          92..131
FT                   /note="WD 2"
FT   REPEAT          134..174
FT                   /note="WD 3"
FT   REPEAT          195..234
FT                   /note="WD 4"
FT   REPEAT          239..278
FT                   /note="WD 5"
FT   REGION          278..309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..294
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   358 AA;  39242 MW;  4A907E07AB9062B2 CRC64;
     MAVKWTGGHS SPILCLNASQ EGLVASGAEG GDLVVWGEDG TLLGHTCFQG AEDVTNVLFS
     PSCPTKLYAS HGETISILDV RSLKEPLDDF HVNEEEINCL SLNETENLLA SADDSGTIKI
     LDLENKKISR SLKRHSNICS SVAFRPQRPQ SLVSCGLDMQ VMLWNLRKAR PLWITNLQED
     ETEEMESPQS PGQLLNPALA HSVSVASCGN VFSCGAEDGK VRIFRVMGVK CEQELGFKGH
     SLGVSQVCFL RESYLLLTGG NDGKIKLWDV SSEIEKKHKS PTKHTHRKKT KRAAYTKQGG
     GTHASVTGED EHGKILPKLS IEHGEKVNWL LSTKIKGYRN ILVADQTSCI SVYPLKEF