ID   WDR53_CAEEL             Reviewed;         501 AA.
AC   Q23256;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=WD repeat-containing protein wdr-5.3;
GN   Name=wdr-5.3; Synonyms=swd-3.3; ORFNames=ZC302.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION.
RX   PubMed=21455483; DOI=10.1371/journal.pgen.1001349;
RA   Li T., Kelly W.G.;
RT   "A role for Set1/MLL-related components in epigenetic regulation of the
RT   Caenorhabditis elegans germ line.";
RL   PLoS Genet. 7:E1001349-E1001349(2011).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=24682813; DOI=10.1093/nar/gku221;
RA   Li T., Kelly W.G.;
RT   "A role for WDR5 in TRA-1/Gli mediated transcriptional control of the
RT   sperm/oocyte switch in C. elegans.";
RL   Nucleic Acids Res. 42:5567-5581(2014).
CC   -!- FUNCTION: Not required for methylation of histone H3 'Lys-4'.
CC       {ECO:0000269|PubMed:21455483, ECO:0000269|PubMed:24682813}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown does not result in
CC       detectable defects in histone H3 'Lys-4' di- or tri-methylation in
CC       embryos or adults germ cells at 20 or 25 degrees Celsius.
CC       {ECO:0000269|PubMed:24682813}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR5/wds family. {ECO:0000305}.
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DR   EMBL; Z73978; CAA98293.1; -; Genomic_DNA.
DR   PIR; T27513; T27513.
DR   RefSeq; NP_001024299.1; NM_001029128.3.
DR   AlphaFoldDB; Q23256; -.
DR   SMR; Q23256; -.
DR   BioGRID; 44518; 2.
DR   STRING; 6239.ZC302.2a; -.
DR   EPD; Q23256; -.
DR   PaxDb; Q23256; -.
DR   PeptideAtlas; Q23256; -.
DR   EnsemblMetazoa; ZC302.2a.1; ZC302.2a.1; WBGene00013862.
DR   GeneID; 179489; -.
DR   KEGG; cel:CELE_ZC302.2; -.
DR   UCSC; ZC302.2a; c. elegans.
DR   CTD; 179489; -.
DR   WormBase; ZC302.2a; CE06574; WBGene00013862; wdr-5.3.
DR   eggNOG; KOG0266; Eukaryota.
DR   GeneTree; ENSGT00970000196638; -.
DR   HOGENOM; CLU_000288_57_1_1; -.
DR   InParanoid; Q23256; -.
DR   OrthoDB; 957291at2759; -.
DR   PhylomeDB; Q23256; -.
DR   PRO; PR:Q23256; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00013862; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0044666; C:MLL3/4 complex; IDA:WormBase.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..501
FT                   /note="WD repeat-containing protein wdr-5.3"
FT                   /id="PRO_0000051502"
FT   REPEAT          211..241
FT                   /note="WD 1"
FT   REPEAT          253..283
FT                   /note="WD 2"
FT   REPEAT          295..325
FT                   /note="WD 3"
FT   REPEAT          337..367
FT                   /note="WD 4"
FT   REPEAT          381..410
FT                   /note="WD 5"
FT   REPEAT          422..455
FT                   /note="WD 6"
FT   REPEAT          467..499
FT                   /note="WD 7"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          58..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          155..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..80
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        155..177
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   501 AA;  54474 MW;  DB22116996F85988 CRC64;
     MNPERQETIS PKNVPFQPVP TPNQQSLQSR MLESNQAVPD AFQKVAAWNH YNAVATPPIG
     VPQTARPPSN QSPHPNPPGY PYQSHQQQFH PLAIAFQQPF GLPQQVIYPP PPPGFTPHRV
     QVSPVGLLGP PGFFPQFAGS TTSQGNPSEV SVRTKSAEGT TGPIAPSITT KPTSTIQVAP
     PRDPVAPTTS SSGITKKPEN GEFSLVKTIS GHTKSVSVIK FSYCGKYLGT GSADKQIKVW
     NTVDMTYLQT LASHQLGIND FSWSSNSQFI ASASDDTTVK IFDVISGACL RTMRGHTNYV
     FCCSFNPQSS LIASAGFDET VRVWDFKTGL CVKCIPAHSD PITSISYNHD GNTMATSSYD
     GCIRVWDAAS GSCLKTLVDT DHAPVTFVCF SPNGKYLLSA QLDSSLKLWD PKKAKPLKYY
     NGHKNKKYCL FANMSVPLGK HIISGSEDGR ILVWSIQTKQ IVQILEGHTT PVLATDSHPT
     LNIIASGGLE PDNVIRIWRR N