ID   WDR53_DICDI             Reviewed;         368 AA.
AC   Q54BI5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=WD repeat-containing protein 53 homolog;
GN   Name=wdr53; ORFNames=DDB_G0293608;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the WD repeat WDR53 family. {ECO:0000305}.
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DR   EMBL; AAFI02000218; EAL60616.1; -; Genomic_DNA.
DR   RefSeq; XP_629044.1; XM_629042.1.
DR   AlphaFoldDB; Q54BI5; -.
DR   SMR; Q54BI5; -.
DR   STRING; 44689.DDB0266374; -.
DR   PaxDb; Q54BI5; -.
DR   EnsemblProtists; EAL60616; EAL60616; DDB_G0293608.
DR   GeneID; 8629330; -.
DR   KEGG; ddi:DDB_G0293608; -.
DR   dictyBase; DDB_G0293608; wdr53.
DR   eggNOG; ENOG502QQ86; Eukaryota.
DR   HOGENOM; CLU_057939_1_0_1; -.
DR   InParanoid; Q54BI5; -.
DR   OMA; EINCLSV; -.
DR   PhylomeDB; Q54BI5; -.
DR   PRO; PR:Q54BI5; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR042453; WDR53.
DR   PANTHER; PTHR44666; PTHR44666; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..368
FT                   /note="WD repeat-containing protein 53 homolog"
FT                   /id="PRO_0000328054"
FT   REPEAT          27..66
FT                   /note="WD 1"
FT   REPEAT          71..108
FT                   /note="WD 2"
FT   REPEAT          116..155
FT                   /note="WD 3"
FT   REPEAT          159..199
FT                   /note="WD 4"
FT   REPEAT          228..267
FT                   /note="WD 5"
FT   REPEAT          271..315
FT                   /note="WD 6"
FT   REGION          207..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   368 AA;  41988 MW;  8E94C06A445D6665 CRC64;
     MTSVDINNNN NNNNNSNSNI IETKLIGHKD TVLCISSHNK KEIIASGSDD CTVRIWDLNT
     NKSIQSIVEG FQGNPVNNVC FDQDFTLYCS YDNIIVSFDL RQPNVILKEF NTQYKFNTEE
     INQLSFDSKY QYLAACDDSG QTKIIDVTKN KLVESLNKKH TNIATGCVFR PNSKNELITS
     SMDFSIIHWD FLKAKVLHRD TFKEGSLPQN ISKSQQQQQE TTEPNRMLNP PFVTSVDCSN
     NSKYVAISMG DGTIVINEIS SFKQYLKINS IHKSSIQQVH YPKYLENNYQ RLISFGNYDK
     KIVIWDVSED MNTKVSSSLL SNDEKNNERI KTWLEHSEKI NCLTTSNLKN NAIFVADLSN
     DLKLLSIQ