WDR53_MOUSE
ID WDR53_MOUSE Reviewed; 358 AA.
AC Q9DB94;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=WD repeat-containing protein 53;
GN Name=Wdr53;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the WD repeat WDR53 family. {ECO:0000305}.
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DR EMBL; AK005105; BAB23821.1; -; mRNA.
DR EMBL; BC028850; AAH28850.1; -; mRNA.
DR CCDS; CCDS28118.1; -.
DR RefSeq; NP_001172091.1; NM_001185162.1.
DR RefSeq; NP_081174.1; NM_026898.2.
DR RefSeq; XP_006522573.1; XM_006522510.3.
DR AlphaFoldDB; Q9DB94; -.
DR SMR; Q9DB94; -.
DR STRING; 10090.ENSMUSP00000023474; -.
DR iPTMnet; Q9DB94; -.
DR PhosphoSitePlus; Q9DB94; -.
DR EPD; Q9DB94; -.
DR MaxQB; Q9DB94; -.
DR PaxDb; Q9DB94; -.
DR PeptideAtlas; Q9DB94; -.
DR PRIDE; Q9DB94; -.
DR ProteomicsDB; 275202; -.
DR Antibodypedia; 2878; 66 antibodies from 17 providers.
DR Ensembl; ENSMUST00000023474; ENSMUSP00000023474; ENSMUSG00000022787.
DR Ensembl; ENSMUST00000178573; ENSMUSP00000135908; ENSMUSG00000022787.
DR GeneID; 68980; -.
DR KEGG; mmu:68980; -.
DR UCSC; uc007yym.2; mouse.
DR CTD; 348793; -.
DR MGI; MGI:1916230; Wdr53.
DR VEuPathDB; HostDB:ENSMUSG00000022787; -.
DR eggNOG; ENOG502QQ86; Eukaryota.
DR GeneTree; ENSGT00390000011073; -.
DR HOGENOM; CLU_057939_1_0_1; -.
DR InParanoid; Q9DB94; -.
DR OMA; EINCLSV; -.
DR OrthoDB; 1551636at2759; -.
DR PhylomeDB; Q9DB94; -.
DR TreeFam; TF331160; -.
DR BioGRID-ORCS; 68980; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Wdr53; mouse.
DR PRO; PR:Q9DB94; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9DB94; protein.
DR Bgee; ENSMUSG00000022787; Expressed in spermatid and 206 other tissues.
DR ExpressionAtlas; Q9DB94; baseline and differential.
DR Genevisible; Q9DB94; MM.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR042453; WDR53.
DR PANTHER; PTHR44666; PTHR44666; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..358
FT /note="WD repeat-containing protein 53"
FT /id="PRO_0000051414"
FT REPEAT 8..47
FT /note="WD 1"
FT REPEAT 92..131
FT /note="WD 2"
FT REPEAT 134..174
FT /note="WD 3"
FT REPEAT 195..234
FT /note="WD 4"
FT REPEAT 239..278
FT /note="WD 5"
FT REGION 288..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 358 AA; 38642 MW; 4371E639E8DC4009 CRC64;
MAVKWTGGHS SSILCLNANK DGLVASGGEG GDLVAWGEDG TPLGHMQLEG ADDVTSVLFS
ASCPTKLYAS HGETISVLDV RSLKGSLDHF HVNEEEINCL SLNETESLLA SADDSGAIKI
LDLEKKKVTR SLKRHSNICS SVAFRPQRPQ SLVSCGLDMQ VMLWSLQKAR PVWITNLQED
ETEETEGPQT PGRLLNPALA HSVSVASCGN IFSCGAEDGK VRIFRVMGVK CERELGFKGH
TLGVSQVCFL PESSLLLTGG NDGRIRLWDV SGKMEKLQKS PARHIHRKKA KRAACPTQGG
NSRAPGAEDE GHAKILPKLD IEHGEKVNWL LSTKIKGNKS ILVADQTSCV SVYPLNEL
