ID   WDR55_BOVIN             Reviewed;         382 AA.
AC   Q58DT8; A1L559;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=WD repeat-containing protein 55;
GN   Name=WDR55;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Nucleolar protein that acts as a modulator of rRNA synthesis.
CC       Plays a central role during organogenesis (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Cytoplasm
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR55 family. {ECO:0000305}.
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DR   EMBL; BT021509; AAX46356.1; -; mRNA.
DR   EMBL; BT029846; ABM06102.1; -; mRNA.
DR   EMBL; BC102226; AAI02227.1; -; mRNA.
DR   RefSeq; NP_001014873.1; NM_001014873.1.
DR   AlphaFoldDB; Q58DT8; -.
DR   SMR; Q58DT8; -.
DR   STRING; 9913.ENSBTAP00000020021; -.
DR   PaxDb; Q58DT8; -.
DR   Ensembl; ENSBTAT00000020021; ENSBTAP00000020021; ENSBTAG00000015042.
DR   GeneID; 508709; -.
DR   KEGG; bta:508709; -.
DR   CTD; 54853; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015042; -.
DR   VGNC; VGNC:36906; WDR55.
DR   eggNOG; KOG2444; Eukaryota.
DR   GeneTree; ENSGT00940000153727; -.
DR   HOGENOM; CLU_035848_0_1_1; -.
DR   InParanoid; Q58DT8; -.
DR   OMA; QTHHPHD; -.
DR   OrthoDB; 1173229at2759; -.
DR   TreeFam; TF315175; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000015042; Expressed in digestive system secreted substance and 104 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR017422; WDR55.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 1.
DR   PIRSF; PIRSF038169; WD_repeat_p55; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW   rRNA processing; WD repeat.
FT   CHAIN           1..382
FT                   /note="WD repeat-containing protein 55"
FT                   /id="PRO_0000237597"
FT   REPEAT          36..75
FT                   /note="WD 1"
FT   REPEAT          82..121
FT                   /note="WD 2"
FT   REPEAT          125..163
FT                   /note="WD 3"
FT   REPEAT          166..205
FT                   /note="WD 4"
FT   REPEAT          208..247
FT                   /note="WD 5"
FT   REPEAT          250..289
FT                   /note="WD 6"
FT   REPEAT          293..332
FT                   /note="WD 7"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         14
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6Y2"
FT   MOD_RES         354
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6Y2"
FT   MOD_RES         381
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6Y2"
SQ   SEQUENCE   382 AA;  42046 MW;  0474A886452552B4 CRC64;
     MDRMCEERAA EDGSDEEDPD ATEAPARIRD TPEDIVLEAP ASGLAFHPAR DLLAAGDVDG
     DVFVFSYSCQ EGETKELWSS GHHLKSCRAV VFSEDGQKLV TVSKDKAIHF LDVELGRLER
     RISKAHGAPI NSLLLVDENV LATGDDTGGI RLWDQRKEGP LMDMRQHEEY IADMALDPDK
     KLLLTASGDG CLGVFNIKRR RFELLSEPQS GDLTSVTLMK YGRKVACGSS EGTIYLFNWD
     GFGATSDRFA LRAESIDCMV PVTESLLCAG STDGVIRAVN ILPNRVVGSV GQHAEEPVEN
     LALSHCGCFL ASSGHDQRLK FWDMAQLRAL VVDDYRRRKK KGGPLRALSS KAWSTDDFFA
     GLREEGEDAK TLEEEESEDD SD