ID   WDR55_DANRE             Reviewed;         387 AA.
AC   Q6DRF9; Q502U3;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=WD repeat-containing protein 55;
GN   Name=wdr55;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15256591; DOI=10.1073/pnas.0403929101;
RA   Amsterdam A., Nissen R.M., Sun Z., Swindell E.C., Farrington S.,
RA   Hopkins N.;
RT   "Identification of 315 genes essential for early zebrafish development.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:12792-12797(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=18769712; DOI=10.1371/journal.pgen.1000171;
RA   Iwanami N., Higuchi T., Sasano Y., Fujiwara T., Hoa V.Q., Okada M.,
RA   Talukder S.R., Kunimatsu S., Li J., Saito F., Bhattacharya C., Matin A.,
RA   Sasaki T., Shimizu N., Mitani H., Himmelbauer H., Momoi A., Kondoh H.,
RA   Furutani-Seiki M., Takahama Y.;
RT   "WDR55 is a nucleolar modulator of ribosomal RNA synthesis, cell cycle
RT   progression, and teleost organ development.";
RL   PLoS Genet. 4:E1000171-E1000171(2008).
CC   -!- FUNCTION: Nucleolar protein that acts as a modulator of rRNA synthesis.
CC       Plays a central role during organogenesis (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Death between 10 and 12 dpf. Thymus size is
CC       remarkably reduced and the pharyngeal arches are malformed. Eyes and
CC       swim bladder are also reduced. {ECO:0000269|PubMed:18769712}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR55 family. {ECO:0000305}.
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DR   EMBL; AY648800; AAT68118.1; -; mRNA.
DR   EMBL; BC095552; AAH95552.1; -; mRNA.
DR   RefSeq; NP_001003871.1; NM_001003871.2.
DR   AlphaFoldDB; Q6DRF9; -.
DR   SMR; Q6DRF9; -.
DR   STRING; 7955.ENSDARP00000018714; -.
DR   PaxDb; Q6DRF9; -.
DR   DNASU; 445394; -.
DR   GeneID; 445394; -.
DR   KEGG; dre:445394; -.
DR   CTD; 54853; -.
DR   ZFIN; ZDB-GENE-040924-7; wdr55.
DR   eggNOG; KOG2444; Eukaryota.
DR   InParanoid; Q6DRF9; -.
DR   OrthoDB; 1173229at2759; -.
DR   PhylomeDB; Q6DRF9; -.
DR   PRO; PR:Q6DRF9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0001654; P:eye development; IMP:UniProtKB.
DR   GO; GO:0060465; P:pharynx development; IMP:UniProtKB.
DR   GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR   GO; GO:0048794; P:swim bladder development; IMP:UniProtKB.
DR   GO; GO:0048538; P:thymus development; IMP:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR017422; WDR55.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   PIRSF; PIRSF038169; WD_repeat_p55; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; rRNA processing; WD repeat.
FT   CHAIN           1..387
FT                   /note="WD repeat-containing protein 55"
FT                   /id="PRO_0000373955"
FT   REPEAT          33..72
FT                   /note="WD 1"
FT   REPEAT          79..118
FT                   /note="WD 2"
FT   REPEAT          122..160
FT                   /note="WD 3"
FT   REPEAT          163..202
FT                   /note="WD 4"
FT   REPEAT          205..244
FT                   /note="WD 5"
FT   REPEAT          247..286
FT                   /note="WD 6"
FT   REPEAT          290..329
FT                   /note="WD 7"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          356..387
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        368..387
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        5
FT                   /note="T -> I (in Ref. 1; AAT68118)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        15
FT                   /note="V -> E (in Ref. 1; AAT68118)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        22
FT                   /note="T -> P (in Ref. 1; AAT68118)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        373..375
FT                   /note="NDE -> DD (in Ref. 1; AAT68118)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   387 AA;  43172 MW;  F561D9DA55367353 CRC64;
     MATPTEHEDL SEQEVTEDEF KTPKIRETPE DIKLEAIVNT IAFHPKQDIL AAGDIDGDIY
     LFSYSCTEGE NKELWSSGHH LKSCRKVLFS SDGQKLFSVS KDKAIHIMDV EAGKLETRIP
     KAHKVPINAM LLIDENIFAT GDDEGTLKVW DMRKGTSFMD LKHHEDYISD ITIDQAKRTL
     LTSSGDGTLG VFNIKRRRFE LLSEIQNGDL TSVSIMKRGR KVVCGSGEGT IYIFNWNGFG
     ATSDRFAVQA ESVDCIVPIT DSILCAASTD GVIRAINILP NRVVGSIGQH VGEAIEEIAR
     CRDTHFLASC AHDELIKFWD ISSLPDEKVN DYRRRKKKDR RLKALSNKAF DTGQNFFAGL
     LDTTEENGKE GENDEDDDDE DSDSGSD