WDR55_DROME
ID WDR55_DROME Reviewed; 498 AA.
AC Q8T088; Q9VGI7;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=WD repeat-containing protein 55 homolog;
GN ORFNames=CG14722;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- SIMILARITY: Belongs to the WD repeat WDR55 family. {ECO:0000305}.
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DR EMBL; AE014297; AAF54692.2; -; Genomic_DNA.
DR EMBL; AY069480; AAL39625.1; -; mRNA.
DR RefSeq; NP_650111.3; NM_141854.4.
DR AlphaFoldDB; Q8T088; -.
DR SMR; Q8T088; -.
DR BioGRID; 66544; 1.
DR STRING; 7227.FBpp0081907; -.
DR PaxDb; Q8T088; -.
DR PRIDE; Q8T088; -.
DR DNASU; 41419; -.
DR EnsemblMetazoa; FBtr0082431; FBpp0081907; FBgn0037943.
DR GeneID; 41419; -.
DR KEGG; dme:Dmel_CG14722; -.
DR UCSC; CG14722-RA; d. melanogaster.
DR FlyBase; FBgn0037943; CG14722.
DR VEuPathDB; VectorBase:FBgn0037943; -.
DR eggNOG; KOG2444; Eukaryota.
DR GeneTree; ENSGT00940000153727; -.
DR HOGENOM; CLU_035848_1_0_1; -.
DR InParanoid; Q8T088; -.
DR OMA; QTHHPHD; -.
DR OrthoDB; 1173229at2759; -.
DR PhylomeDB; Q8T088; -.
DR BioGRID-ORCS; 41419; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 41419; -.
DR PRO; PR:Q8T088; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0037943; Expressed in oviduct (Drosophila) and 50 other tissues.
DR Genevisible; Q8T088; DM.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IMP:FlyBase.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR024977; Apc4_WD40_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..498
FT /note="WD repeat-containing protein 55 homolog"
FT /id="PRO_0000373961"
FT REPEAT 154..193
FT /note="WD 1"
FT REPEAT 198..237
FT /note="WD 2"
FT REPEAT 241..279
FT /note="WD 3"
FT REPEAT 282..321
FT /note="WD 4"
FT REPEAT 324..363
FT /note="WD 5"
FT REPEAT 408..447
FT /note="WD 6"
FT REGION 1..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..27
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 498 AA; 55322 MW; E5A7461FDA619AD3 CRC64;
MHTHNNFKTP SDEDELDDLD EDMVVGVIAE IEQEVLNESD SDNDEYDLVD MGAPVPDNDG
DISYEGNDSS SSDDSFDPNA ADSDSDDSML DEAGGVTAGG ATSAKKRKDD DNPSGSNKQP
EATFDLDEDD ETDETVRAMI AAIKKPRSSP PEIKLEDFIT DICFHPDRDI IALATIIGDV
HLYEYDNEAN KLLRTIEVHS KACRDVEFTE DGRFLLTCSK DKCVMVTDME TEKLKKLYET
AHDDAINTLH VLNENLFASG DDAGTVKLWD LRTKNAIFEL KELEDQITQL TTNEQSKLLL
ATSADGYLTT FNISARKMYV QSEPYEEELN CMGVYRGDSK LVVGTSKGRL YTYNWGQFGY
HCDMYPGIKS PISLMIPITD RIACVAGEDG NIRACHIAPY RNLGVVGQHN MPIESLDVNA
SGELIASSSH NNDVRFWNVK YFEDFGDIKY NEKHNAYKEQ RHNLPSSKCS NASDFFSDLT
KENADGDDDP GAGPSNMA
