ID   WDR55_DROPE             Reviewed;         503 AA.
AC   B4GMG4;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=WD repeat-containing protein 55 homolog;
GN   ORFNames=GL12389;
OS   Drosophila persimilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7234;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSH-3 / Tucson 14011-0111.49;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SIMILARITY: Belongs to the WD repeat WDR55 family. {ECO:0000305}.
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DR   EMBL; CH479185; EDW38038.1; -; Genomic_DNA.
DR   RefSeq; XP_002019404.1; XM_002019368.1.
DR   AlphaFoldDB; B4GMG4; -.
DR   SMR; B4GMG4; -.
DR   STRING; 7234.FBpp0176496; -.
DR   EnsemblMetazoa; FBtr0178004; FBpp0176496; FBgn0149996.
DR   GeneID; 6594719; -.
DR   KEGG; dpe:6594719; -.
DR   eggNOG; KOG2444; Eukaryota.
DR   HOGENOM; CLU_035848_1_0_1; -.
DR   OMA; QTHHPHD; -.
DR   PhylomeDB; B4GMG4; -.
DR   Proteomes; UP000008744; Unassembled WGS sequence.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:EnsemblMetazoa.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..503
FT                   /note="WD repeat-containing protein 55 homolog"
FT                   /id="PRO_0000373963"
FT   REPEAT          157..196
FT                   /note="WD 1"
FT   REPEAT          201..242
FT                   /note="WD 2"
FT   REPEAT          244..282
FT                   /note="WD 3"
FT   REPEAT          285..324
FT                   /note="WD 4"
FT   REPEAT          327..366
FT                   /note="WD 5"
FT   REPEAT          411..450
FT                   /note="WD 6"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          35..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          483..503
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..78
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..98
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   503 AA;  55690 MW;  35F53B1E83CD9C59 CRC64;
     MHTHNNFKTP SDADELDDLD DDMVIGVIEE IAQEALVGED VSDSDIDEHD LADVGAPEHN
     QNADENESIS SDSSFDPNAE DSSDSDDSML EEDEAEGASS GEATSAKRRK DDNDGPCGSA
     ADSAAVDLDD LDDETDETVR AIIAAIKKPR SAPPEIKLED FITDVCFHPD RDIIALATII
     GDVHLYEYGN EGNKLLRTIE VHSKACRDVE FTEDGRYLLT ASKDKCVMVT DLETEKLKKL
     YETAHDDAIN KLHVLDENLF ATGDDAGTVK LWDLRTKNPI FELKEVEDQI TQMITNDQKK
     LLLATSADGY LTTFNIAARK LYVQSEPYEE ELNCMGIYRG SSKLVVGTSK GKLYSYNWGY
     FGYHCDMYPG IKSPVSLMIP ITDRIACVAG EDGNIRACHI TPYRNLGVVG QHNMPIESLD
     INTSGELLAS SSHNNDVRFW NVKYFEDFGD IKYNDKHNAY KEKRHNLPSS KCTNASDFFS
     DLTKEDEDNA DNNDAAAGPS NSA