ID   WDR55_DROPS             Reviewed;         503 AA.
AC   Q294Y7;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 2.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=WD repeat-containing protein 55 homolog;
GN   ORFNames=GA13204;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- SIMILARITY: Belongs to the WD repeat WDR55 family. {ECO:0000305}.
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DR   EMBL; CM000070; EAL28825.2; -; Genomic_DNA.
DR   RefSeq; XP_001359675.2; XM_001359638.4.
DR   AlphaFoldDB; Q294Y7; -.
DR   SMR; Q294Y7; -.
DR   STRING; 7237.FBpp0281274; -.
DR   EnsemblMetazoa; FBtr0282836; FBpp0281274; FBgn0073241.
DR   GeneID; 4802839; -.
DR   KEGG; dpo:Dpse_GA13204; -.
DR   eggNOG; KOG2444; Eukaryota.
DR   HOGENOM; CLU_035848_1_0_1; -.
DR   InParanoid; Q294Y7; -.
DR   OMA; QTHHPHD; -.
DR   Proteomes; UP000001819; Chromosome 2.
DR   Bgee; FBgn0073241; Expressed in female reproductive system and 2 other tissues.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:EnsemblMetazoa.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..503
FT                   /note="WD repeat-containing protein 55 homolog"
FT                   /id="PRO_0000373964"
FT   REPEAT          157..196
FT                   /note="WD 1"
FT   REPEAT          201..242
FT                   /note="WD 2"
FT   REPEAT          244..282
FT                   /note="WD 3"
FT   REPEAT          285..324
FT                   /note="WD 4"
FT   REPEAT          327..366
FT                   /note="WD 5"
FT   REPEAT          411..450
FT                   /note="WD 6"
FT   REGION          1..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          483..503
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..52
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..78
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..98
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   503 AA;  55818 MW;  872710FBAECCEAC0 CRC64;
     MHTHNNFKTP SDADELDDLD DDMVIGVIEE IAQEALVGED ESDSDIDEHD LADMEAPEPN
     QNADENESIS SDSSFDPNAE DSSDSDDSML EEDEAEGASS GEATSAKRRK DDNDGPCGSA
     GDSAAFDLDD LDDETDETVR AIIAAIKKPR SAPPEIKLED FITDVCFHPD RDIIALATII
     GDVHLYEYGN EGNKLLRTIE VHSKACRDVE FTEDGRYLLT ASKDKCVMVT DLETEKLKKL
     YETAHDDAIN KLHVLDENLF ATGDDAGTVK LWDLRTKNPI FELKEVEDQI TQMITNDQKK
     LLLATSADGY LTTFNIAARK LYVQSEPYEE ELNCMGIYRG SSKLVVGTSK GKLYSYNWGY
     FGYHCDMYPG IKSPVSLMIP ITDRIACVAG EDGNIRACHI TPYRNLGVVG QHNMPIESLD
     INTSGELLAS SSHNNDVRFW NVKYFEDFGD IKYNDKHNAY KEKRHNLPSS KCTNASDFFS
     DLTKEDEDNA DNNDAAAGPS NSA