ID   WDR55_DROSI             Reviewed;         498 AA.
AC   B4QTL6;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=WD repeat-containing protein 55 homolog;
GN   ORFNames=GD18783;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SIMILARITY: Belongs to the WD repeat WDR55 family. {ECO:0000305}.
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DR   EMBL; CM000364; EDX13321.1; -; Genomic_DNA.
DR   RefSeq; XP_002103818.1; XM_002103782.2.
DR   AlphaFoldDB; B4QTL6; -.
DR   SMR; B4QTL6; -.
DR   STRING; 7240.B4QTL6; -.
DR   EnsemblMetazoa; FBtr0218693; FBpp0217185; FBgn0190302.
DR   GeneID; 6728473; -.
DR   HOGENOM; CLU_035848_1_0_1; -.
DR   OMA; QTHHPHD; -.
DR   PhylomeDB; B4QTL6; -.
DR   Proteomes; UP000000304; Chromosome 3r.
DR   Bgee; FBgn0190302; Expressed in embryo and 3 other tissues.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:EnsemblMetazoa.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..498
FT                   /note="WD repeat-containing protein 55 homolog"
FT                   /id="PRO_0000373965"
FT   REPEAT          154..193
FT                   /note="WD 1"
FT   REPEAT          198..237
FT                   /note="WD 2"
FT   REPEAT          241..279
FT                   /note="WD 3"
FT   REPEAT          282..321
FT                   /note="WD 4"
FT   REPEAT          324..363
FT                   /note="WD 5"
FT   REPEAT          408..447
FT                   /note="WD 6"
FT   REGION          1..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..27
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..78
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   498 AA;  55355 MW;  B2E2C5D0363B7B0F CRC64;
     MHTHNNFKTP SDEDELDDLD EDMVVGVIAE IEQEVLNESD SDNDEYDLVD MGAPVPDNDG
     DVSYDGNDSI SSDDSFDPNA ADSDSDDSML DEAGGGSAGG ATSAKKRKDD DNPSGSNKQP
     EATFDLDEDD ETDETVRAMI AAIKKPRSSP PEIKLEDFIT DICFHPDRDI IALATIIGDV
     HLYEYDNEAN KLLRTIEVHS KACRDVEFTE DGRFLLTCSK DKCVMVTDME TEKLKKLYET
     AHDDAINTLH VLNENLFASG DDAGTVKLWD LRTKNAIFEL KELEDQITQL TTNEQSKLLL
     ATSADGYLTT FNISARKMYV QSEPYEEELN CMGVYRGDSK LVVGTSKGRL YTYNWGQFGY
     HCDMYPGIKS PISLMIPITD RIACVAGEDG NIRACHIAPY RNLGVVGQHN MPIESLDVNA
     SGELIASSSH NNDVRFWNVK YFEDFGEIKY NEKHNAYKEQ RHNLPSSKCS NTSDFFADLT
     KEDADGDDDP CAGPSNMS