WDR55_MOUSE
ID WDR55_MOUSE Reviewed; 388 AA.
AC Q9CX97; A2RS10;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=WD repeat-containing protein 55;
GN Name=Wdr55;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Lung, and Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX PubMed=18769712; DOI=10.1371/journal.pgen.1000171;
RA Iwanami N., Higuchi T., Sasano Y., Fujiwara T., Hoa V.Q., Okada M.,
RA Talukder S.R., Kunimatsu S., Li J., Saito F., Bhattacharya C., Matin A.,
RA Sasaki T., Shimizu N., Mitani H., Himmelbauer H., Momoi A., Kondoh H.,
RA Furutani-Seiki M., Takahama Y.;
RT "WDR55 is a nucleolar modulator of ribosomal RNA synthesis, cell cycle
RT progression, and teleost organ development.";
RL PLoS Genet. 4:E1000171-E1000171(2008).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Nucleolar protein that acts as a modulator of rRNA synthesis.
CC Plays a central role during organogenesis.
CC {ECO:0000269|PubMed:18769712}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:18769712}.
CC Cytoplasm {ECO:0000269|PubMed:18769712}.
CC -!- DISRUPTION PHENOTYPE: Death before implantation of the embryo.
CC {ECO:0000269|PubMed:18769712}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR55 family. {ECO:0000305}.
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DR EMBL; AK018469; BAB31225.2; -; mRNA.
DR EMBL; AK075958; BAC36082.1; -; mRNA.
DR EMBL; AK146093; BAE26896.1; -; mRNA.
DR EMBL; CH466557; EDK97176.1; -; Genomic_DNA.
DR EMBL; BC131932; AAI31933.1; -; mRNA.
DR EMBL; BC131934; AAI31935.1; -; mRNA.
DR CCDS; CCDS29162.1; -.
DR RefSeq; NP_080740.2; NM_026464.2.
DR AlphaFoldDB; Q9CX97; -.
DR SMR; Q9CX97; -.
DR BioGRID; 212549; 1.
DR IntAct; Q9CX97; 1.
DR STRING; 10090.ENSMUSP00000039010; -.
DR iPTMnet; Q9CX97; -.
DR PhosphoSitePlus; Q9CX97; -.
DR EPD; Q9CX97; -.
DR MaxQB; Q9CX97; -.
DR PaxDb; Q9CX97; -.
DR PeptideAtlas; Q9CX97; -.
DR PRIDE; Q9CX97; -.
DR ProteomicsDB; 297894; -.
DR Antibodypedia; 45472; 34 antibodies from 15 providers.
DR DNASU; 67936; -.
DR Ensembl; ENSMUST00000049323; ENSMUSP00000039010; ENSMUSG00000042660.
DR GeneID; 67936; -.
DR KEGG; mmu:67936; -.
DR UCSC; uc008eol.1; mouse.
DR CTD; 54853; -.
DR MGI; MGI:1915186; Wdr55.
DR VEuPathDB; HostDB:ENSMUSG00000042660; -.
DR eggNOG; KOG2444; Eukaryota.
DR GeneTree; ENSGT00940000153727; -.
DR HOGENOM; CLU_035848_0_1_1; -.
DR InParanoid; Q9CX97; -.
DR OMA; QTHHPHD; -.
DR OrthoDB; 1173229at2759; -.
DR PhylomeDB; Q9CX97; -.
DR TreeFam; TF315175; -.
DR BioGRID-ORCS; 67936; 25 hits in 62 CRISPR screens.
DR ChiTaRS; Wdr55; mouse.
DR PRO; PR:Q9CX97; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q9CX97; protein.
DR Bgee; ENSMUSG00000042660; Expressed in ectoplacental cone and 158 other tissues.
DR ExpressionAtlas; Q9CX97; baseline and differential.
DR Genevisible; Q9CX97; MM.
DR GO; GO:0005737; C:cytoplasm; IMP:UniProtKB.
DR GO; GO:0005730; C:nucleolus; IMP:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0006364; P:rRNA processing; IMP:UniProtKB.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR024977; Apc4_WD40_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR017422; WDR55.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 1.
DR PIRSF; PIRSF038169; WD_repeat_p55; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW rRNA processing; WD repeat.
FT CHAIN 1..388
FT /note="WD repeat-containing protein 55"
FT /id="PRO_0000237599"
FT REPEAT 37..76
FT /note="WD 1"
FT REPEAT 83..122
FT /note="WD 2"
FT REPEAT 126..164
FT /note="WD 3"
FT REPEAT 167..206
FT /note="WD 4"
FT REPEAT 209..248
FT /note="WD 5"
FT REPEAT 251..290
FT /note="WD 6"
FT REPEAT 293..333
FT /note="WD 7"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 355
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H6Y2"
SQ SEQUENCE 388 AA; 42611 MW; ED6B412A9B0DF369 CRC64;
MDPTCEESPA EDSNNEEEDL DSTKAAPRIR DTPEDIVLEA PASGLAFHPT RDLLAAGDVD
GDVFVFAYSC QEGETKELWS SGHHLKSCRA VVFSEDGQKL VTVSKDKAIH ILDVEQGQLE
RRISKAHSAP INSVLLVDEN ALVTGDDTGG IRLWDQRKEG PLMDMRQHEE YIADMALDPA
KKLLLTASGD GCLGVFNIKR RRFELLSEPQ SGDLTSVALM KYGKKVACGS SEGTIYLFNW
NGFGATSDRF ALRAESIDCI VPVTENLLCT GSTDGIIRAV NILPNRVVGT VGQHAGEPVE
ALALSHCGHF LASSGHDQRL KFWDMTQLRT VVVDDYRRRK KKGGPLRALS SKAWSTDDFF
AGLREDEEDA KAPEEVVRES DDDDDDSD
