ID   WDR55_ORYLA             Reviewed;         400 AA.
AC   B2ZZS9;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=WD repeat-containing protein 55;
DE   AltName: Full=Protein hokecha;
GN   Name=wdr55;
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF GLY-112.
RC   STRAIN=Carolina Biological;
RX   PubMed=18769712; DOI=10.1371/journal.pgen.1000171;
RA   Iwanami N., Higuchi T., Sasano Y., Fujiwara T., Hoa V.Q., Okada M.,
RA   Talukder S.R., Kunimatsu S., Li J., Saito F., Bhattacharya C., Matin A.,
RA   Sasaki T., Shimizu N., Mitani H., Himmelbauer H., Momoi A., Kondoh H.,
RA   Furutani-Seiki M., Takahama Y.;
RT   "WDR55 is a nucleolar modulator of ribosomal RNA synthesis, cell cycle
RT   progression, and teleost organ development.";
RL   PLoS Genet. 4:E1000171-E1000171(2008).
CC   -!- FUNCTION: Nucleolar protein that acts as a modulator of rRNA synthesis.
CC       Plays a central role during organogenesis, including thymus
CC       development. {ECO:0000269|PubMed:18769712}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:18769712}.
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC       {ECO:0000269|PubMed:18769712}.
CC   -!- DISRUPTION PHENOTYPE: Death between 8 and 10 dpf due to multiple
CC       defects in organogenesis. Thymus primordium fails to accumulate
CC       lymphoid cells. The head, the eyes, the liver and the gall bladder are
CC       smaller. Pharyngeal arches are abnormally shaped and lower jaws are
CC       malformed. In contrast, hematopoiesis and development of the gills and
CC       the gut, as well as body axis formation, are not disturbed at 7 dpf.
CC       {ECO:0000269|PubMed:18769712}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR55 family. {ECO:0000305}.
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DR   EMBL; AB372859; BAG41964.1; -; mRNA.
DR   RefSeq; NP_001129989.1; NM_001136517.1.
DR   AlphaFoldDB; B2ZZS9; -.
DR   SMR; B2ZZS9; -.
DR   STRING; 8090.ENSORLP00000002972; -.
DR   GeneID; 100192344; -.
DR   KEGG; ola:100192344; -.
DR   CTD; 54853; -.
DR   eggNOG; KOG2444; Eukaryota.
DR   InParanoid; B2ZZS9; -.
DR   OrthoDB; 1173229at2759; -.
DR   Proteomes; UP000001038; Unplaced.
DR   Proteomes; UP000265180; Chromosome 9.
DR   Proteomes; UP000265200; Chromosome 9.
DR   GO; GO:0005730; C:nucleolus; IDA:UniProtKB.
DR   GO; GO:0001654; P:eye development; IMP:UniProtKB.
DR   GO; GO:0060322; P:head development; IMP:UniProtKB.
DR   GO; GO:0001889; P:liver development; IMP:UniProtKB.
DR   GO; GO:0060465; P:pharynx development; IMP:UniProtKB.
DR   GO; GO:0006364; P:rRNA processing; IMP:UniProtKB.
DR   GO; GO:0048536; P:spleen development; IMP:UniProtKB.
DR   GO; GO:0048538; P:thymus development; IMP:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR017422; WDR55.
DR   PIRSF; PIRSF038169; WD_repeat_p55; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome; Repeat; rRNA processing; WD repeat.
FT   CHAIN           1..400
FT                   /note="WD repeat-containing protein 55"
FT                   /id="PRO_0000373956"
FT   REPEAT          52..91
FT                   /note="WD 1"
FT   REPEAT          98..137
FT                   /note="WD 2"
FT   REPEAT          141..179
FT                   /note="WD 3"
FT   REPEAT          182..221
FT                   /note="WD 4"
FT   REPEAT          224..263
FT                   /note="WD 5"
FT   REPEAT          266..305
FT                   /note="WD 6"
FT   REPEAT          309..348
FT                   /note="WD 7"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          356..400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        383..400
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MUTAGEN         112
FT                   /note="G->R: In hkc; death between 8 and 10 dpf. Impairs
FT                   localization into the nucleolus."
FT                   /evidence="ECO:0000269|PubMed:18769712"
SQ   SEQUENCE   400 AA;  44384 MW;  57E722C76602443E CRC64;
     MAAPPEHAAT GSEQTDPPET NSEPDLSQPE PADSDADEPV GPKIRETPED IRLEAIANTV
     ALHPSRDVLV CGDVDGDVYA YAYSCTEGET RELWSSGHHL KSCRQVRFSA DGLKLYSVSR
     DKAVHQLDVE RGQLVSRIRG AHAAAINSLL LVDENILATG DDRGTLKVWD MRKGEAFMDL
     KHHDDYISDI AVDQAKRILL TTSGDGTMGV FNIKRRRFEL LSEFQSGDLT SVALMKRGKK
     VVCGSSEGTV YIFNWNGFGA TSDRFAVKAE SVDCIVPITD SIMCTASMDG YIRAINLLPN
     RVIGCIGQHV GEPIEEINKS WDSRFLVSCA HDQLIKFWEI SNLQKTTVSD YRKRKKKDGR
     MKSLTKKALG DNDFFSGLVE ETEKKEEEEE EEEDSDSDSD