ID   WDR55_PONAB             Reviewed;         383 AA.
AC   Q5R9T6;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=WD repeat-containing protein 55;
GN   Name=WDR55;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Nucleolar protein that acts as a modulator of rRNA synthesis.
CC       Plays a central role during organogenesis (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Cytoplasm
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR55 family. {ECO:0000305}.
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DR   EMBL; CR859296; CAH91474.1; -; mRNA.
DR   RefSeq; NP_001125868.1; NM_001132396.1.
DR   AlphaFoldDB; Q5R9T6; -.
DR   SMR; Q5R9T6; -.
DR   STRING; 9601.ENSPPYP00000017738; -.
DR   GeneID; 100172799; -.
DR   KEGG; pon:100172799; -.
DR   CTD; 54853; -.
DR   eggNOG; KOG2444; Eukaryota.
DR   InParanoid; Q5R9T6; -.
DR   OrthoDB; 1173229at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR017422; WDR55.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 1.
DR   PIRSF; PIRSF038169; WD_repeat_p55; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW   rRNA processing; WD repeat.
FT   CHAIN           1..383
FT                   /note="WD repeat-containing protein 55"
FT                   /id="PRO_0000237600"
FT   REPEAT          36..75
FT                   /note="WD 1"
FT   REPEAT          82..121
FT                   /note="WD 2"
FT   REPEAT          125..163
FT                   /note="WD 3"
FT   REPEAT          166..205
FT                   /note="WD 4"
FT   REPEAT          208..247
FT                   /note="WD 5"
FT   REPEAT          250..289
FT                   /note="WD 6"
FT   REPEAT          293..332
FT                   /note="WD 7"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          362..383
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         14
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6Y2"
FT   MOD_RES         354
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6Y2"
FT   MOD_RES         378
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6Y2"
FT   MOD_RES         382
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6Y2"
SQ   SEQUENCE   383 AA;  41984 MW;  1EF131C712DB267F CRC64;
     MDRTCEERPA EDGSDEEDPD SMEAPTRIRD TPEDIVLEAP ASGLAFHPAR DLLAAGDVDG
     DVFVFSYSCQ EGETKELWSS GHHLKACRAV AFSEDGQKLV TVSKDKAIHV LDVEQGRLER
     RISKAHGAPI NSLLLVDENV LATGDDMGGI RLWDQRKEGP LMDMRQHEEY IADMALDPAK
     KLLLTASGDG CLGVFNIKRR RFELLSEPQS GDLTSVTLMK CGKKVACGSS EGTIYLFNWN
     GFGATSDRFA LRAESIDCMV PVTESLLCTG STDGVIRAVN ILPNRVVGSV GQHTGEPVGE
     LALSHCGRFL ASSGHDQRLK FWDMAQLRAV VVDDYRQRKK KGGPLRALSS KTWSTDDFFA
     GLREEGEDSM AQEEKEETGD DSD