ID   WDR55_RAT               Reviewed;         384 AA.
AC   A1L112;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=WD repeat-containing protein 55;
GN   Name=Wdr55;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Nucleolar protein that acts as a modulator of rRNA synthesis.
CC       Plays a central role during organogenesis (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Cytoplasm
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR55 family. {ECO:0000305}.
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DR   EMBL; CH473974; EDL76316.1; -; Genomic_DNA.
DR   EMBL; BC127460; AAI27461.1; -; mRNA.
DR   RefSeq; NP_001017932.1; NM_001017932.1.
DR   AlphaFoldDB; A1L112; -.
DR   SMR; A1L112; -.
DR   BioGRID; 258736; 1.
DR   STRING; 10116.ENSRNOP00000044213; -.
DR   iPTMnet; A1L112; -.
DR   PhosphoSitePlus; A1L112; -.
DR   jPOST; A1L112; -.
DR   PaxDb; A1L112; -.
DR   PeptideAtlas; A1L112; -.
DR   GeneID; 307494; -.
DR   KEGG; rno:307494; -.
DR   UCSC; RGD:1305640; rat.
DR   CTD; 54853; -.
DR   RGD; 1305640; Wdr55.
DR   eggNOG; KOG2444; Eukaryota.
DR   HOGENOM; CLU_328704_0_0_1; -.
DR   InParanoid; A1L112; -.
DR   OrthoDB; 1173229at2759; -.
DR   PRO; PR:A1L112; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Proteomes; UP000234681; Chromosome 18.
DR   Genevisible; A1L112; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR017422; WDR55.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 1.
DR   PIRSF; PIRSF038169; WD_repeat_p55; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW   rRNA processing; WD repeat.
FT   CHAIN           1..384
FT                   /note="WD repeat-containing protein 55"
FT                   /id="PRO_0000373954"
FT   REPEAT          36..75
FT                   /note="WD 1"
FT   REPEAT          82..121
FT                   /note="WD 2"
FT   REPEAT          125..163
FT                   /note="WD 3"
FT   REPEAT          166..205
FT                   /note="WD 4"
FT   REPEAT          208..247
FT                   /note="WD 5"
FT   REPEAT          250..289
FT                   /note="WD 6"
FT   REPEAT          293..332
FT                   /note="WD 7"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          362..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         354
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6Y2"
FT   MOD_RES         383
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6Y2"
SQ   SEQUENCE   384 AA;  42142 MW;  13BDE7C63355DA29 CRC64;
     MDPTCQESPA EDSNNEEDLD STKAAPRIRD TPEDIVLEAP ASGLAFHPTR DLLAAGDVDG
     DVFVFAYSCQ EGETKELWSS GHHLKSCRAV VFSEDGQKLV TVSKDKAIHV LDVEQGQLER
     RISKAHSAPI NSLLLVDENV LVTGDDTGGI RLWDQRKEGP LMDMRQHEEY IADMALDPAK
     KLLLTASGDG CLGVFNIKRR RFELLSEPQS GDLTSVALMK YGKKVACGSS EGTIYLFNWN
     GFGATSDRFA LRAESIDCMV PVTENLLCTG STDGIIRAVN ILPNRVVGTV GQHAGEPVEE
     LALSHCGHFL ASSGHDQRLK FWDMTQLRTV VVDDYRRRKK KGGPLRALSS KAWSTDDFFA
     GLREDEEEAK APEEVSGESD DDSD