ID   WDR59_CHICK             Reviewed;         973 AA.
AC   Q5ZLG9;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=GATOR complex protein WDR59 {ECO:0000305};
GN   Name=WDR59 {ECO:0000250|UniProtKB:Q6PJI9};
GN   ORFNames=RCJMB04_6d21 {ECO:0000312|EMBL:CAG31424.1};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: As a component of the GATOR complex may function in the amino
CC       acid-sensing branch of the TORC1 signaling pathway.
CC       {ECO:0000250|UniProtKB:Q9NXC5}.
CC   -!- SUBUNIT: Probably part of the GATOR complex.
CC       {ECO:0000250|UniProtKB:Q96S15}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q96S15}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR59 family. {ECO:0000305}.
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DR   EMBL; AJ719765; CAG31424.1; -; mRNA.
DR   RefSeq; NP_001012794.1; NM_001012776.1.
DR   AlphaFoldDB; Q5ZLG9; -.
DR   SMR; Q5ZLG9; -.
DR   STRING; 9031.ENSGALP00000004419; -.
DR   PaxDb; Q5ZLG9; -.
DR   Ensembl; ENSGALT00000004428; ENSGALP00000004419; ENSGALG00000002798.
DR   GeneID; 415688; -.
DR   KEGG; gga:415688; -.
DR   CTD; 79726; -.
DR   VEuPathDB; HostDB:geneid_415688; -.
DR   eggNOG; KOG0264; Eukaryota.
DR   eggNOG; KOG0309; Eukaryota.
DR   GeneTree; ENSGT00940000157600; -.
DR   HOGENOM; CLU_009370_0_0_1; -.
DR   InParanoid; Q5ZLG9; -.
DR   OMA; HDACIPF; -.
DR   OrthoDB; 590848at2759; -.
DR   PhylomeDB; Q5ZLG9; -.
DR   TreeFam; TF314695; -.
DR   Reactome; R-GGA-9639288; Amino acids regulate mTORC1.
DR   PRO; PR:Q5ZLG9; -.
DR   Proteomes; UP000000539; Chromosome 11.
DR   Bgee; ENSGALG00000002798; Expressed in testis and 13 other tissues.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   GO; GO:0035859; C:Seh1-associated complex; IBA:GO_Central.
DR   GO; GO:0005774; C:vacuolar membrane; IBA:GO_Central.
DR   GO; GO:0035591; F:signaling adaptor activity; IBA:GO_Central.
DR   GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR   GO; GO:1904263; P:positive regulation of TORC1 signaling; IBA:GO_Central.
DR   CDD; cd16692; mRING-H2-C3H3C2_WDR59; 1.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR006575; RWD-domain.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR039456; WDR59_mRING-H2-C3H3C2.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00591; RWD; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
DR   PROSITE; PS50908; RWD; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Lysosome; Membrane; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..973
FT                   /note="GATOR complex protein WDR59"
FT                   /id="PRO_0000280723"
FT   REPEAT          57..98
FT                   /note="WD 1"
FT   REPEAT          103..143
FT                   /note="WD 2"
FT   REPEAT          146..185
FT                   /note="WD 3"
FT   REPEAT          189..229
FT                   /note="WD 4"
FT   REPEAT          232..276
FT                   /note="WD 5"
FT   REPEAT          280..324
FT                   /note="WD 6"
FT   DOMAIN          393..494
FT                   /note="RWD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00179"
FT   REGION          346..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   973 AA;  109882 MW;  52722760595953E0 CRC64;
     MAARWSSENV VVEFRDAQAT AMSVDCLGQH AVLSGRRFLY IVNLDAPNEG HRKISRQSKW
     DIGAVQWNPH DSYAYYFAAS SNQRVDLYKW KEGNGEVCTS LQGHTRVISD LDWSVFEPDL
     LVTSSVDTYI YIWDIKDTRK PTVSLSAVAG ASQVKWNKKN ANCLATSHDG DVRIWDKRKP
     STAVEYLAAH LSKIHGLDWH PDNEYTLATS SQDNSVRFWD YRQPRKYLNI LPCQVPVWKA
     RYTPFSNGLV TVMVPQLRRE NSLLLWNVFD LNTPVHTFVG HDDVVLEFQW RKQKEGSKDY
     QLVTWSRDQT LRMWRIDSQL QRLCANDILD GVDDLIDGIS LLPEPDKALQ PQDSEPQHSS
     GHGDEEALKE DFLNDLLVGK KTDQLGLPQT LQQEFSLINV QIRNVNVEMD AVNRSCTVSV
     HCGNHRVRML VMFPVQYPNN AAPSFQFINP TSITASMKAK LLKILKDTSL QKVKRNQSCL
     EPCLRQLVSW LESVVNQEDS TSSNPYALPN SVTTPLPTFA RVSNAYGSYQ DSNIPFPRTS
     GARFCGAGYL VYFTRPMTMH RAVSPTEPTP RSLSALSAYH SGLITPMKIR TETPGNLRLY
     SGSPTRSEKE QVSISSFYYK ERKSRRWKSK REGTDANNRP IKAAGKVIIQ DISCLLPVHK
     LLGELYILNV NNIQETCQKN AASAMAVGRR DLVQVWSLAM VATDLCLGPK SDPDLEIPWA
     QHPFGRQLLE SLLAHYSQLH DVQTLAMLCS VFEAQSRLQG CPNSYGPFPQ RASNLASHSR
     YPSFTSSGSC SSMSDPGLGT GGWSIANKDT EQTSTPWCES SPDEFRYSNL MYPDHREREK
     DQHEKNKRLL DPANTQQFDD FKKCYGEILY RWGLREKRAE VLKFVSSPPD PHKGIEFGVY
     CSHCRSEARG TQCAICKGFT FQCAICHVAV RGSSNFCLTC GHGGHTSHMM EWFRTQEVCP
     TGCGCHCLLE STF