WDR5B_ARATH
ID WDR5B_ARATH Reviewed; 333 AA.
AC Q9SY00;
DT 04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 149.
DE RecName: Full=COMPASS-like H3K4 histone methylase component WDR5B {ECO:0000303|PubMed:19567704};
DE Short=AtWDR5B {ECO:0000303|PubMed:19567704};
GN Name=WDR5B {ECO:0000303|PubMed:19567704};
GN OrderedLocusNames=At4g02730 {ECO:0000312|Araport:AT4G02730};
GN ORFNames=T5J8.2 {ECO:0000312|EMBL:AAD15347.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP DISRUPTION PHENOTYPE.
RX PubMed=19567704; DOI=10.1105/tpc.109.067967;
RA Jiang D., Gu X., He Y.;
RT "Establishment of the winter-annual growth habit via FRIGIDA-mediated
RT histone methylation at FLOWERING LOCUS C in Arabidopsis.";
RL Plant Cell 21:1733-1746(2009).
RN [6]
RP LACK OF INTERACTION WITH RBL AND TRO.
RX PubMed=21423667; DOI=10.1371/journal.pgen.1001330;
RA Jiang D., Kong N.C., Gu X., Li Z., He Y.;
RT "Arabidopsis COMPASS-like complexes mediate histone H3 lysine-4
RT trimethylation to control floral transition and plant development.";
RL PLoS Genet. 7:E1001330-E1001330(2011).
CC -!- SUBUNIT: Unlike WDR5A, does not interact with RBL or TRO.
CC {ECO:0000269|PubMed:21423667}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC {ECO:0000269|PubMed:19567704}.
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DR EMBL; AC004044; AAD15347.1; -; Genomic_DNA.
DR EMBL; AL161495; CAB77758.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE82221.1; -; Genomic_DNA.
DR EMBL; AF439825; AAL27497.1; -; mRNA.
DR EMBL; AY088121; AAM65666.1; -; mRNA.
DR EMBL; AY125558; AAM78068.1; -; mRNA.
DR PIR; G85034; G85034.
DR RefSeq; NP_192182.1; NM_116507.3.
DR AlphaFoldDB; Q9SY00; -.
DR SMR; Q9SY00; -.
DR STRING; 3702.AT4G02730.1; -.
DR PaxDb; Q9SY00; -.
DR PRIDE; Q9SY00; -.
DR ProteomicsDB; 242574; -.
DR EnsemblPlants; AT4G02730.1; AT4G02730.1; AT4G02730.
DR GeneID; 828189; -.
DR Gramene; AT4G02730.1; AT4G02730.1; AT4G02730.
DR KEGG; ath:AT4G02730; -.
DR Araport; AT4G02730; -.
DR TAIR; locus:2140215; AT4G02730.
DR eggNOG; KOG0266; Eukaryota.
DR HOGENOM; CLU_000288_57_1_1; -.
DR InParanoid; Q9SY00; -.
DR OMA; NYALKCT; -.
DR OrthoDB; 957291at2759; -.
DR PhylomeDB; Q9SY00; -.
DR PRO; PR:Q9SY00; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9SY00; baseline and differential.
DR Genevisible; Q9SY00; AT.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:TAIR.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..333
FT /note="COMPASS-like H3K4 histone methylase component WDR5B"
FT /id="PRO_0000431783"
FT REPEAT 1..40
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 41..80
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 83..122
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 126..167
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 169..207
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 211..252
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 253..295
FT /note="WD 7"
FT /evidence="ECO:0000255"
FT REPEAT 298..333
FT /note="WD 8"
FT /evidence="ECO:0000255"
SQ SEQUENCE 333 AA; 36303 MW; 1A275A9EA88E39C3 CRC64;
MPSGGNGTSN GVANANSTGN AGTSGNVPIY KPYRHLKTLE GHTAAISCVK FSNDGNLLAS
ASVDKTMILW SATNYSLIHR YEGHSSGISD LAWSSDSHYT CSASDDCTLR IWDARSPYEC
LKVLRGHTNF VFCVNFNPPS NLIVSGSFDE TIRIWEVKTG KCVRMIKAHS MPISSVHFNR
DGSLIVSASH DGSCKIWDAK EGTCLKTLID DKSPAVSFAK FSPNGKFILV ATLDSTLKLS
NYATGKFLKV YTGHTNKVFC ITSAFSVTNG KYIVSGSEDN CVYLWDLQAR NILQRLEGHT
DAVISVSCHP VQNEISSSGN HLDKTIRIWK QDA