WDR5B_HUMAN
ID WDR5B_HUMAN Reviewed; 330 AA.
AC Q86VZ2; B2RCM9; Q9NUL4;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=WD repeat-containing protein 5B;
GN Name=WDR5B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta, and Subthalamic nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May function as a substrate receptor for CUL4-DDB1 ubiquitin
CC E3 ligase complex. {ECO:0000250}.
CC -!- SUBUNIT: Probable part of a cullin-RING E3 protein ligase complex
CC containing CUL4B-DDB1 and a substrate-recruiting component (DCAF).
CC Interacts with CUL4B and DDB1 (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR5/wds family. {ECO:0000305}.
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DR EMBL; AK002149; BAA92110.1; -; mRNA.
DR EMBL; AK315186; BAG37626.1; -; mRNA.
DR EMBL; CR457279; CAG33560.1; -; mRNA.
DR EMBL; CH471052; EAW79485.1; -; Genomic_DNA.
DR EMBL; BC043494; AAH43494.1; -; mRNA.
DR CCDS; CCDS3012.1; -.
DR RefSeq; NP_061942.2; NM_019069.3.
DR AlphaFoldDB; Q86VZ2; -.
DR SMR; Q86VZ2; -.
DR BioGRID; 120039; 54.
DR CORUM; Q86VZ2; -.
DR IntAct; Q86VZ2; 25.
DR STRING; 9606.ENSP00000330381; -.
DR iPTMnet; Q86VZ2; -.
DR PhosphoSitePlus; Q86VZ2; -.
DR BioMuta; WDR5B; -.
DR DMDM; 74762455; -.
DR jPOST; Q86VZ2; -.
DR MassIVE; Q86VZ2; -.
DR MaxQB; Q86VZ2; -.
DR PaxDb; Q86VZ2; -.
DR PeptideAtlas; Q86VZ2; -.
DR PRIDE; Q86VZ2; -.
DR ProteomicsDB; 70093; -.
DR Antibodypedia; 51262; 75 antibodies from 18 providers.
DR DNASU; 54554; -.
DR Ensembl; ENST00000330689.6; ENSP00000330381.4; ENSG00000196981.4.
DR GeneID; 54554; -.
DR KEGG; hsa:54554; -.
DR MANE-Select; ENST00000330689.6; ENSP00000330381.4; NM_019069.4; NP_061942.2.
DR UCSC; uc003efa.2; human.
DR CTD; 54554; -.
DR DisGeNET; 54554; -.
DR GeneCards; WDR5B; -.
DR HGNC; HGNC:17826; WDR5B.
DR HPA; ENSG00000196981; Low tissue specificity.
DR neXtProt; NX_Q86VZ2; -.
DR OpenTargets; ENSG00000196981; -.
DR PharmGKB; PA38248; -.
DR VEuPathDB; HostDB:ENSG00000196981; -.
DR eggNOG; KOG0266; Eukaryota.
DR GeneTree; ENSGT00940000154143; -.
DR HOGENOM; CLU_000288_57_1_1; -.
DR InParanoid; Q86VZ2; -.
DR OMA; NYALKCT; -.
DR OrthoDB; 957291at2759; -.
DR PhylomeDB; Q86VZ2; -.
DR TreeFam; TF314125; -.
DR PathwayCommons; Q86VZ2; -.
DR SignaLink; Q86VZ2; -.
DR BioGRID-ORCS; 54554; 7 hits in 1083 CRISPR screens.
DR GenomeRNAi; 54554; -.
DR Pharos; Q86VZ2; Tdark.
DR PRO; PR:Q86VZ2; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q86VZ2; protein.
DR Bgee; ENSG00000196981; Expressed in bronchial epithelial cell and 145 other tissues.
DR Genevisible; Q86VZ2; HS.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0051568; P:histone H3-K4 methylation; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT CHAIN 1..330
FT /note="WD repeat-containing protein 5B"
FT /id="PRO_0000278461"
FT REPEAT 39..78
FT /note="WD 1"
FT REPEAT 81..122
FT /note="WD 2"
FT REPEAT 124..164
FT /note="WD 3"
FT REPEAT 165..204
FT /note="WD 4"
FT REPEAT 208..249
FT /note="WD 5"
FT REPEAT 252..292
FT /note="WD 6"
FT REPEAT 295..330
FT /note="WD 7"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 188..192
FT /note="DDB1-binding motif"
FT COMPBIAS 10..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 251
FT /note="H -> Q (in Ref. 1; BAA92110)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 330 AA; 36338 MW; C2C47476F24716D5 CRC64;
MATKESRDAK AQLALSSSAN QSKEVPENPN YALKCTLVGH TEAVSSVKFS PNGEWLASSS
ADRLIIIWGA YDGKYEKTLY GHNLEISDVA WSSDSSRLVS ASDDKTLKLW DVRSGKCLKT
LKGHSNYVFC CNFNPPSNLI ISGSFDETVK IWEVKTGKCL KTLSAHSDPV SAVHFNCSGS
LIVSGSYDGL CRIWDAASGQ CLKTLVDDDN PPVSFVKFSP NGKYILTATL DNTLKLWDYS
RGRCLKTYTG HKNEKYCIFA NFSVTGGKWI VSGSEDNLVY IWNLQTKEIV QKLQGHTDVV
ISAACHPTEN LIASAALEND KTIKLWMSNH
