WDR5B_MOUSE
ID WDR5B_MOUSE Reviewed; 328 AA.
AC Q9D7H2;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=WD repeat-containing protein 5B;
GN Name=Wdr5b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INTERACTION WITH CUL4B AND DDB1.
RX PubMed=17041588; DOI=10.1038/ncb1490;
RA Higa L.A., Wu M., Ye T., Kobayashi R., Sun H., Zhang H.;
RT "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins
RT and regulates histone methylation.";
RL Nat. Cell Biol. 8:1277-1283(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Liver, Ovary, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May function as a substrate receptor for CUL4-DDB1 ubiquitin
CC E3 ligase complex. {ECO:0000269|PubMed:17041588}.
CC -!- SUBUNIT: Probable part of a cullin-RING E3 protein ligase complex
CC containing CUL4B-DDB1 and a substrate-recruiting component (DCAF).
CC Interacts with CUL4B and DDB1. {ECO:0000269|PubMed:17041588}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR5/wds family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EF011616; ABK41106.1; -; mRNA.
DR EMBL; AK009247; BAB26165.1; -; mRNA.
DR EMBL; AK149554; BAE28955.1; -; mRNA.
DR EMBL; AK165100; BAE38035.1; -; mRNA.
DR EMBL; BC064045; AAH64045.1; -; mRNA.
DR CCDS; CCDS28145.1; -.
DR RefSeq; NP_081389.1; NM_027113.2.
DR AlphaFoldDB; Q9D7H2; -.
DR SMR; Q9D7H2; -.
DR STRING; 10090.ENSMUSP00000040852; -.
DR PhosphoSitePlus; Q9D7H2; -.
DR MaxQB; Q9D7H2; -.
DR PaxDb; Q9D7H2; -.
DR PRIDE; Q9D7H2; -.
DR ProteomicsDB; 299668; -.
DR Antibodypedia; 51262; 75 antibodies from 18 providers.
DR Ensembl; ENSMUST00000042203; ENSMUSP00000040852; ENSMUSG00000034379.
DR GeneID; 69544; -.
DR KEGG; mmu:69544; -.
DR UCSC; uc007zcc.1; mouse.
DR CTD; 54554; -.
DR MGI; MGI:1916794; Wdr5b.
DR VEuPathDB; HostDB:ENSMUSG00000034379; -.
DR eggNOG; KOG0266; Eukaryota.
DR GeneTree; ENSGT00940000154143; -.
DR HOGENOM; CLU_000288_57_1_1; -.
DR InParanoid; Q9D7H2; -.
DR OMA; NYALKCT; -.
DR OrthoDB; 957291at2759; -.
DR PhylomeDB; Q9D7H2; -.
DR TreeFam; TF314125; -.
DR BioGRID-ORCS; 69544; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Wdr5b; mouse.
DR PRO; PR:Q9D7H2; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9D7H2; protein.
DR Bgee; ENSMUSG00000034379; Expressed in retinal neural layer and 149 other tissues.
DR Genevisible; Q9D7H2; MM.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0051568; P:histone H3-K4 methylation; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT CHAIN 1..328
FT /note="WD repeat-containing protein 5B"
FT /id="PRO_0000278462"
FT REPEAT 37..76
FT /note="WD 1"
FT REPEAT 79..120
FT /note="WD 2"
FT REPEAT 122..162
FT /note="WD 3"
FT REPEAT 163..202
FT /note="WD 4"
FT REPEAT 206..247
FT /note="WD 5"
FT REPEAT 250..290
FT /note="WD 6"
FT REPEAT 293..328
FT /note="WD 7"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 186..190
FT /note="DDB1-binding motif"
SQ SEQUENCE 328 AA; 36033 MW; 359C55AFE4BF608A CRC64;
MATEHLPAER AQSLLSAPRR EEEPQKPNYA LRLTLAGHSA AISSVKFSPN GEWLASSAAD
ALIIIWGAYD GNCKKTLYGH SLEISDVAWS SDSSRLVSAS DDKTLKVWDM RSGKCLKTLK
GHSDFVFCCD FNPPSNLIVS GSFDESVKIW EVKTGKCLKT LSAHSDPISA VNFNCNGSLI
VSGSYDGLCR IWDAASGQCL RTLADEGNPP VSFVKFSPNG KYILTATLDN TLKLWDYSRG
RCLKTYTGHK NEKYCLFASF SVTGRKWVVS GSEDNMVYIW NLQTKEIVQR LQGHTDVVIS
AACHPTKNII ASAALENDKT IKVWSSDC
