ID   WDR5B_PONAB             Reviewed;         330 AA.
AC   Q5RE95;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=WD repeat-containing protein 5B;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a substrate receptor for CUL4-DDB1 ubiquitin
CC       E3 ligase complex. {ECO:0000250}.
CC   -!- SUBUNIT: Probable part of a cullin-RING E3 protein ligase complex
CC       containing CUL4B-DDB1 and a substrate-recruiting component (DCAF).
CC       Interacts with CUL4B and DDB1 (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR5/wds family. {ECO:0000305}.
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DR   EMBL; CR857638; CAH89912.1; -; mRNA.
DR   RefSeq; NP_001127213.1; NM_001133741.1.
DR   AlphaFoldDB; Q5RE95; -.
DR   SMR; Q5RE95; -.
DR   STRING; 9601.ENSPPYP00000015083; -.
DR   Ensembl; ENSPPYT00000015685; ENSPPYP00000015083; ENSPPYG00000013484.
DR   GeneID; 100174268; -.
DR   KEGG; pon:100174268; -.
DR   CTD; 54554; -.
DR   eggNOG; KOG0266; Eukaryota.
DR   GeneTree; ENSGT00940000154143; -.
DR   HOGENOM; CLU_000288_57_1_1; -.
DR   InParanoid; Q5RE95; -.
DR   OMA; NYALKCT; -.
DR   OrthoDB; 957291at2759; -.
DR   TreeFam; TF314125; -.
DR   Proteomes; UP000001595; Chromosome 3.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..330
FT                   /note="WD repeat-containing protein 5B"
FT                   /id="PRO_0000278463"
FT   REPEAT          39..78
FT                   /note="WD 1"
FT   REPEAT          81..122
FT                   /note="WD 2"
FT   REPEAT          124..164
FT                   /note="WD 3"
FT   REPEAT          165..204
FT                   /note="WD 4"
FT   REPEAT          208..249
FT                   /note="WD 5"
FT   REPEAT          252..292
FT                   /note="WD 6"
FT   REPEAT          295..330
FT                   /note="WD 7"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           188..192
FT                   /note="DDB1-binding motif"
FT   COMPBIAS        10..26
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   330 AA;  36299 MW;  28EA8994207B7D11 CRC64;
     MATKESGDAK AQLALSSSAN QSKEVPENPN YALKCTLVGH TEAVSSVKFS PNGEWLASSS
     ADRLIIIWGA YDGKYERTLY GHNLEISDVA WSSDSSRLVS ASDDKTLKLW DMRSGKCLKT
     LKGHSNYVFC CNFNPPSNLI ISGSFDETVK IWEVKTGKCL KTLSAHSDPV SAVHFNCSGS
     LIVSGSYDGL CRIWDAASGQ CLKTLVDDDN PPVSFVKFSP NGKYILTATL DNTLKLWDYS
     RGRCLKTYTG HKNEKYCIFA NFSVTGGKWI VSGSEDNLVY IWNLQTKEIV QKLQGHTDVV
     ISAACHPTEN LIASAALEND KTIKLWMSNH