ID   WDR5B_RAT               Reviewed;         328 AA.
AC   Q4V8C4;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=WD repeat-containing protein 5B;
GN   Name=Wdr5b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May function as a substrate receptor for CUL4-DDB1 ubiquitin
CC       E3 ligase complex. {ECO:0000250}.
CC   -!- SUBUNIT: Probable part of a cullin-RING E3 protein ligase complex
CC       containing CUL4B-DDB1 and a substrate-recruiting component (DCAF).
CC       Interacts with CUL4B and DDB1 (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR5/wds family. {ECO:0000305}.
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DR   EMBL; BC097449; AAH97449.1; -; mRNA.
DR   RefSeq; NP_001019937.1; NM_001024766.1.
DR   AlphaFoldDB; Q4V8C4; -.
DR   SMR; Q4V8C4; -.
DR   STRING; 10116.ENSRNOP00000003068; -.
DR   iPTMnet; Q4V8C4; -.
DR   PhosphoSitePlus; Q4V8C4; -.
DR   PaxDb; Q4V8C4; -.
DR   PRIDE; Q4V8C4; -.
DR   Ensembl; ENSRNOT00000003068; ENSRNOP00000003068; ENSRNOG00000002253.
DR   GeneID; 303907; -.
DR   KEGG; rno:303907; -.
DR   UCSC; RGD:1308567; rat.
DR   CTD; 54554; -.
DR   RGD; 1308567; Wdr5b.
DR   eggNOG; KOG0266; Eukaryota.
DR   GeneTree; ENSGT00940000154143; -.
DR   HOGENOM; CLU_000288_57_1_1; -.
DR   InParanoid; Q4V8C4; -.
DR   OMA; NYALKCT; -.
DR   OrthoDB; 957291at2759; -.
DR   PhylomeDB; Q4V8C4; -.
DR   TreeFam; TF314125; -.
DR   PRO; PR:Q4V8C4; -.
DR   Proteomes; UP000002494; Chromosome 11.
DR   Bgee; ENSRNOG00000002253; Expressed in testis and 19 other tissues.
DR   Genevisible; Q4V8C4; RN.
DR   GO; GO:0048188; C:Set1C/COMPASS complex; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0051568; P:histone H3-K4 methylation; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..328
FT                   /note="WD repeat-containing protein 5B"
FT                   /id="PRO_0000278464"
FT   REPEAT          37..76
FT                   /note="WD 1"
FT   REPEAT          79..120
FT                   /note="WD 2"
FT   REPEAT          122..162
FT                   /note="WD 3"
FT   REPEAT          163..202
FT                   /note="WD 4"
FT   REPEAT          206..247
FT                   /note="WD 5"
FT   REPEAT          250..290
FT                   /note="WD 6"
FT   REPEAT          293..328
FT                   /note="WD 7"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           186..190
FT                   /note="DDB1-binding motif"
SQ   SEQUENCE   328 AA;  36049 MW;  94A7D4E41A054CC2 CRC64;
     MATEHLPAER AQSPLSAPQR VEEPQKPNYA LRLTLAGHSA AISSVKFSPN GEWLASSAAD
     ALIIIWGAYD GKCKKTLYGH SLEISDVAWS SDSSRLVSAS DDKTLKLWDV RSGKCLKTLK
     GHSDFVFCCD FNPPSNLIVS GSFDESVKIW EVKTGKCLKT LSAHSDPISA VHFHCNGSLI
     VSGSYDGLCR IWDAASGQCL RTLADEGNPP VSFVKFSPNG KYILTATLDS TLKLWDYSRG
     RCLKTYTGHK NEKYCIFASF SVTGRKWVVS GSEDNMVYIW NLQTKEIVQR LQGHTDVVIS
     AACHPTENII ASAALENDKT IKIWSSDY