WDR5_DICDI
ID WDR5_DICDI Reviewed; 335 AA.
AC Q54KL5;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=WD repeat-containing protein 5 homolog;
GN Name=wdr5; ORFNames=DDB_G0287273;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBUNIT: May interact with the histone-lysine N-methyltransferase
CC complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR5/wds family. {ECO:0000305}.
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DR EMBL; AAFI02000099; EAL63798.1; -; Genomic_DNA.
DR RefSeq; XP_637302.1; XM_632210.1.
DR AlphaFoldDB; Q54KL5; -.
DR SMR; Q54KL5; -.
DR STRING; 44689.DDB0232948; -.
DR PaxDb; Q54KL5; -.
DR EnsemblProtists; EAL63798; EAL63798; DDB_G0287273.
DR GeneID; 8626039; -.
DR KEGG; ddi:DDB_G0287273; -.
DR dictyBase; DDB_G0287273; wdr5.
DR eggNOG; KOG0266; Eukaryota.
DR HOGENOM; CLU_000288_57_1_1; -.
DR InParanoid; Q54KL5; -.
DR OMA; RLWNYHT; -.
DR PhylomeDB; Q54KL5; -.
DR Reactome; R-DDI-3214841; PKMTs methylate histone lysines.
DR Reactome; R-DDI-3214858; RMTs methylate histone arginines.
DR Reactome; R-DDI-8951664; Neddylation.
DR PRO; PR:Q54KL5; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0035097; C:histone methyltransferase complex; ISS:dictyBase.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; ISS:dictyBase.
DR GO; GO:0051568; P:histone H3-K4 methylation; ISS:dictyBase.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..335
FT /note="WD repeat-containing protein 5 homolog"
FT /id="PRO_0000327608"
FT REPEAT 44..83
FT /note="WD 1"
FT REPEAT 86..127
FT /note="WD 2"
FT REPEAT 129..167
FT /note="WD 3"
FT REPEAT 170..209
FT /note="WD 4"
FT REPEAT 213..252
FT /note="WD 5"
FT REPEAT 256..298
FT /note="WD 6"
FT REPEAT 301..335
FT /note="WD 7"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 335 AA; 37370 MW; A32D14454FFF76AD CRC64;
MESGPASMSS SSSYLYQEQQ QQQPQQTESI PQTPNYILKY TLKGHLKSIS SVKFSPDGKW
LASASADKTI KIWGAYDGKF ERTLEGHKEG ISDIAWSQDS KLICSASDDK TIKIWDVESG
KMVKTLKGHK EYVFGVSFNP QSNLIVSGSF DENVRIWDVN TGECTKMISA HSDPVTGVHF
NRDGTLVVSG SYDGTVRIWD TTTGQLLNTI STEDGKEVSF VKFSPNGKFV LAGTLDNTLR
LWSYNNNKKC LKTYTGHKNE KYCIFSTFSV TCGKWIVTGS EDNLIYIYNL QTREIVQTLA
GHEDVVLTVA CHPTENIIAS GALEKDRSVK IWKHM
