ID   WDR5_XENTR              Reviewed;         334 AA.
AC   Q5M786;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=WD repeat-containing protein 5;
GN   Name=wdr5; ORFNames=TEgg065j14.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Contributes to histone modification. May position the N-
CC       terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part
CC       of the MLL1/MLL complex it is involved in methylation and dimethylation
CC       at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific
CC       tag for epigenetic transcriptional activation. As part of the NSL
CC       complex it may be involved in acetylation of nucleosomal histone H4 on
CC       several lysine residues. May regulate osteoblasts differentiation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with HCFC1. Probable component of complexes involved
CC       in histone modification such as the MLL1/MLL complex and the NSL
CC       complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR5/wds family. {ECO:0000305}.
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DR   EMBL; CR761006; CAJ82141.1; -; mRNA.
DR   EMBL; BC088786; AAH88786.1; -; mRNA.
DR   RefSeq; NP_001011411.1; NM_001011411.2.
DR   AlphaFoldDB; Q5M786; -.
DR   SMR; Q5M786; -.
DR   PaxDb; Q5M786; -.
DR   DNASU; 496891; -.
DR   GeneID; 496891; -.
DR   KEGG; xtr:496891; -.
DR   CTD; 11091; -.
DR   Xenbase; XB-GENE-493883; wdr5.
DR   eggNOG; KOG0266; Eukaryota.
DR   HOGENOM; CLU_000288_57_1_1; -.
DR   InParanoid; Q5M786; -.
DR   OMA; MNFAVWD; -.
DR   OrthoDB; 957291at2759; -.
DR   PhylomeDB; Q5M786; -.
DR   TreeFam; TF314125; -.
DR   Reactome; R-XTR-3214841; PKMTs methylate histone lysines.
DR   Reactome; R-XTR-3214858; RMTs methylate histone arginines.
DR   Reactome; R-XTR-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.
DR   Reactome; R-XTR-8951664; Neddylation.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000019588; Expressed in testis and 14 other tissues.
DR   ExpressionAtlas; Q5M786; differential.
DR   GO; GO:0000123; C:histone acetyltransferase complex; ISS:UniProtKB.
DR   GO; GO:0071339; C:MLL1 complex; ISS:UniProtKB.
DR   GO; GO:0048188; C:Set1C/COMPASS complex; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0051568; P:histone H3-K4 methylation; IBA:GO_Central.
DR   GO; GO:0043984; P:histone H4-K16 acetylation; ISS:UniProtKB.
DR   GO; GO:0043981; P:histone H4-K5 acetylation; ISS:UniProtKB.
DR   GO; GO:0043982; P:histone H4-K8 acetylation; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; WD repeat.
FT   CHAIN           1..334
FT                   /note="WD repeat-containing protein 5"
FT                   /id="PRO_0000286897"
FT   REPEAT          43..82
FT                   /note="WD 1"
FT   REPEAT          85..126
FT                   /note="WD 2"
FT   REPEAT          128..168
FT                   /note="WD 3"
FT   REPEAT          169..208
FT                   /note="WD 4"
FT   REPEAT          212..253
FT                   /note="WD 5"
FT   REPEAT          256..296
FT                   /note="WD 6"
FT   REPEAT          299..333
FT                   /note="WD 7"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..31
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   334 AA;  36685 MW;  78E5269E0904F084 CRC64;
     MATEEKKPET EASKTQSTPS SSNNQSKPAP VKPNYTLKFT LAGHTKAVSS VKFSPNGEWL
     ASSSADKLIK IWGAYDGKFE KTISGHKLGI SDVAWSSDSN LLVSASDDKT LKIWDVSSGK
     CLKTLKGHSN YVFCCNFNPQ SNLIVSGSFD ESVRIWDVKT GKCLKTLPAH SDPVSAVHFN
     RDGSLIVSSS YDGLCRIWDT ASGQCLKTLI DDDNPPVSFV KFSPNGKYIL AATLDNTLKL
     WDYSKGKCLK TYTCHKNEKY CIFANFSVTG GKWIVSGSED NLVYIWNLQT KEVVQKLQGH
     TDVVISTACH PTENIIASAA LENDKTIKLW KSDC