ID   WDR61_BOVIN             Reviewed;         305 AA.
AC   Q32LN7;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=WD repeat-containing protein 61;
DE   Contains:
DE     RecName: Full=WD repeat-containing protein 61, N-terminally processed;
GN   Name=WDR61;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Component of the PAF1 complex, which consists of CDC73, PAF1,
CC       LEO1, CTR9, RTF1 and WDR61 (By similarity). The PAF1 complex interacts
CC       with PHF5A. Within the PAF1 complex interacts directly with PHF5A (By
CC       similarity). Component of the SKI complex which consists of WDR61,
CC       SKIV2L and TTC37 (By similarity). {ECO:0000250|UniProtKB:Q9ERF3,
CC       ECO:0000250|UniProtKB:Q9GZS3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9GZS3}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9GZS3}.
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DR   EMBL; BC109495; AAI09496.1; -; mRNA.
DR   RefSeq; NP_001033186.1; NM_001038097.2.
DR   RefSeq; XP_005221988.1; XM_005221931.3.
DR   AlphaFoldDB; Q32LN7; -.
DR   SMR; Q32LN7; -.
DR   STRING; 9913.ENSBTAP00000021203; -.
DR   PaxDb; Q32LN7; -.
DR   PRIDE; Q32LN7; -.
DR   Ensembl; ENSBTAT00000021203; ENSBTAP00000021203; ENSBTAG00000015944.
DR   GeneID; 513208; -.
DR   KEGG; bta:513208; -.
DR   CTD; 80349; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015944; -.
DR   VGNC; VGNC:50151; WDR61.
DR   eggNOG; KOG4155; Eukaryota.
DR   GeneTree; ENSGT00940000153533; -.
DR   HOGENOM; CLU_000288_57_11_1; -.
DR   InParanoid; Q32LN7; -.
DR   OMA; VGFSPCN; -.
DR   OrthoDB; 1052423at2759; -.
DR   TreeFam; TF324549; -.
DR   Proteomes; UP000009136; Chromosome 21.
DR   Bgee; ENSBTAG00000015944; Expressed in oocyte and 109 other tissues.
DR   ExpressionAtlas; Q32LN7; baseline and differential.
DR   GO; GO:0016593; C:Cdc73/Paf1 complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0000791; C:euchromatin; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0055087; C:Ski complex; ISS:UniProtKB.
DR   GO; GO:0051568; P:histone H3-K4 methylation; IBA:GO_Central.
DR   GO; GO:0080182; P:histone H3-K4 trimethylation; ISS:UniProtKB.
DR   GO; GO:0045638; P:negative regulation of myeloid cell differentiation; ISS:UniProtKB.
DR   GO; GO:0051571; P:positive regulation of histone H3-K4 methylation; ISS:UniProtKB.
DR   GO; GO:2001162; P:positive regulation of histone H3-K79 methylation; ISS:UniProtKB.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; ISS:UniProtKB.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; WD repeat; Wnt signaling pathway.
FT   CHAIN           1..305
FT                   /note="WD repeat-containing protein 61"
FT                   /id="PRO_0000425747"
FT   INIT_MET        1
FT                   /note="Removed; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9GZS3"
FT   CHAIN           2..305
FT                   /note="WD repeat-containing protein 61, N-terminally
FT                   processed"
FT                   /id="PRO_0000245850"
FT   REPEAT          14..57
FT                   /note="WD 1"
FT   REPEAT          62..101
FT                   /note="WD 2"
FT   REPEAT          104..143
FT                   /note="WD 3"
FT   REPEAT          146..187
FT                   /note="WD 4"
FT   REPEAT          188..227
FT                   /note="WD 5"
FT   REPEAT          230..269
FT                   /note="WD 6"
FT   REPEAT          272..305
FT                   /note="WD 7"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9GZS3"
FT   MOD_RES         2
FT                   /note="N-acetylthreonine; in WD repeat-containing protein
FT                   61, N-terminally processed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9GZS3"
SQ   SEQUENCE   305 AA;  33569 MW;  EE16426E2DC0DB9E CRC64;
     MTNQYSILFK QEQAHDDAIW SVAWGSNKKE NSETVVTGSL DDLVKVWKWR DEKLDLQWSL
     EGHQLGVVSV DISHTLPIAA SSSLDAHIRL WDLENGKQIK SIDAGPVDAW TLAFSPDSQY
     LATGTHVGKV NIFGVESGKK EYSLDTRGKF ILSIAYSPDG KYLASGAIDG IINIFDIATG
     KLLHTLEGHA MPIRSLTFSP DSQLLVTASD DGYIKIYDVQ HANLAGTLSG HASWVLNVAF
     CPDDTHFVSS SSDKSVKVWD VGTRTCVHTF FDHQDQVWGV KYNGNGSKIV SVGDDQEIHI
     YDCPI