ID   WDR61_CHICK             Reviewed;         305 AA.
AC   Q5ZJH5;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=WD repeat-containing protein 61;
GN   Name=WDR61; ORFNames=RCJMB04_18b20;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- SUBUNIT: Component of the PAF1 complex, which at least consists of
CC       CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61 (By similarity). The PAF1
CC       complex interacts with PHF5A (By similarity).
CC       {ECO:0000250|UniProtKB:Q9ERF3, ECO:0000250|UniProtKB:Q9GZS3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9GZS3}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9GZS3}.
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DR   EMBL; AJ720459; CAG32118.1; -; mRNA.
DR   RefSeq; NP_001005805.1; NM_001005805.1.
DR   AlphaFoldDB; Q5ZJH5; -.
DR   SMR; Q5ZJH5; -.
DR   STRING; 9031.ENSGALP00000043388; -.
DR   PaxDb; Q5ZJH5; -.
DR   GeneID; 415359; -.
DR   KEGG; gga:415359; -.
DR   CTD; 80349; -.
DR   VEuPathDB; HostDB:geneid_415359; -.
DR   eggNOG; KOG4155; Eukaryota.
DR   InParanoid; Q5ZJH5; -.
DR   OrthoDB; 1052423at2759; -.
DR   PhylomeDB; Q5ZJH5; -.
DR   PRO; PR:Q5ZJH5; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0016593; C:Cdc73/Paf1 complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0000791; C:euchromatin; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0055087; C:Ski complex; ISS:UniProtKB.
DR   GO; GO:0051568; P:histone H3-K4 methylation; IBA:GO_Central.
DR   GO; GO:0080182; P:histone H3-K4 trimethylation; ISS:UniProtKB.
DR   GO; GO:0045638; P:negative regulation of myeloid cell differentiation; ISS:UniProtKB.
DR   GO; GO:0051571; P:positive regulation of histone H3-K4 methylation; ISS:UniProtKB.
DR   GO; GO:2001162; P:positive regulation of histone H3-K79 methylation; ISS:UniProtKB.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..305
FT                   /note="WD repeat-containing protein 61"
FT                   /id="PRO_0000245854"
FT   REPEAT          14..57
FT                   /note="WD 1"
FT   REPEAT          62..101
FT                   /note="WD 2"
FT   REPEAT          104..143
FT                   /note="WD 3"
FT   REPEAT          146..187
FT                   /note="WD 4"
FT   REPEAT          188..227
FT                   /note="WD 5"
FT   REPEAT          230..269
FT                   /note="WD 6"
FT   REPEAT          272..305
FT                   /note="WD 7"
SQ   SEQUENCE   305 AA;  33274 MW;  1B46CA222AC355BC CRC64;
     MTTQYGILFK QEQAHDDAIW SVAWGKNKKN GSETVISGSL DDLVKVWKWN DEKLDLQWTL
     EGHQLGVVSV DISHTGSIAA SSSLDAHIRL WDLETGKQIK SIDAGPVDAW SLAFSPDSQF
     LATGSHVGKV NIFGVETGKK EYSLDTRGKF ILSIAYSPDG KYLASGAIDG IINIFDIATG
     KLLHTLEGHA MPIRSLTFSP DSQLLVTASD DGYIKIYDVQ HANLAGTLSG HGSWVLNVAF
     CPDDTHFVSS SSDKSVKVWD AGTRTCVHTF FDHQDQVWGV KYNGSGSKIV SVGDDQEIHI
     YDCPV