ID   WDR61_DANRE             Reviewed;         305 AA.
AC   Q6P5M2;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=WD repeat-containing protein 61;
GN   Name=wdr61; ORFNames=zgc:77675;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Component of the PAF1 complex, which at least consists of
CC       CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61 (By similarity). The PAF1
CC       complex interacts with PHF5A (By similarity).
CC       {ECO:0000250|UniProtKB:Q9ERF3, ECO:0000250|UniProtKB:Q9GZS3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9GZS3}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9GZS3}.
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DR   EMBL; BC062834; AAH62834.1; -; mRNA.
DR   RefSeq; NP_957147.1; NM_200853.1.
DR   AlphaFoldDB; Q6P5M2; -.
DR   SMR; Q6P5M2; -.
DR   STRING; 7955.ENSDARP00000110861; -.
DR   PRIDE; Q6P5M2; -.
DR   DNASU; 393827; -.
DR   GeneID; 393827; -.
DR   KEGG; dre:393827; -.
DR   CTD; 80349; -.
DR   ZFIN; ZDB-GENE-040426-1851; wdr61.
DR   InParanoid; Q6P5M2; -.
DR   OrthoDB; 1052423at2759; -.
DR   PhylomeDB; Q6P5M2; -.
DR   Reactome; R-DRE-429958; mRNA decay by 3' to 5' exoribonuclease.
DR   Reactome; R-DRE-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-DRE-75955; RNA Polymerase II Transcription Elongation.
DR   Reactome; R-DRE-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
DR   PRO; PR:Q6P5M2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016593; C:Cdc73/Paf1 complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0000791; C:euchromatin; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0055087; C:Ski complex; ISS:UniProtKB.
DR   GO; GO:0051568; P:histone H3-K4 methylation; IBA:GO_Central.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..305
FT                   /note="WD repeat-containing protein 61"
FT                   /id="PRO_0000245855"
FT   REPEAT          14..57
FT                   /note="WD 1"
FT   REPEAT          62..101
FT                   /note="WD 2"
FT   REPEAT          104..143
FT                   /note="WD 3"
FT   REPEAT          146..187
FT                   /note="WD 4"
FT   REPEAT          188..227
FT                   /note="WD 5"
FT   REPEAT          230..269
FT                   /note="WD 6"
FT   REPEAT          272..305
FT                   /note="WD 7"
SQ   SEQUENCE   305 AA;  33336 MW;  DFDDABE8B413739E CRC64;
     MSTQYSILFK QEHAHEDAIW TAAWGRSEKD GSETIVTGSL DDLVKVWKWS DEKLELQWTL
     EGHQLGVVSV NISQNGAIAA SSSLDAHIRL WDLETGKQIK SMDAGPVDAW TVAFSPDSKY
     IATGSHLGKV NIFGVESGKK EHSLDTRGKF ILSIAYSPDG KYLASGAIDG IINIFDIATG
     KLLHTLEGHA MPIRSLTFSP DSQLLVTASD DGYIKIYDVQ HANLAGTLSG HGSWVLSVAF
     SPDDTHFVSS SSDKSIKVWD TSSRSCVNTF FDHQDQVWSV KYNPTGSKIV SAGDDRAIHI
     YDCPM