WDR61_XENLA
ID WDR61_XENLA Reviewed; 305 AA.
AC Q6GMD2;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=WD repeat-containing protein 61;
GN Name=wdr61;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Component of the PAF1 complex, which at least consists of
CC CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61 (By similarity). The PAF1
CC complex interacts with PHF5A (By similarity).
CC {ECO:0000250|UniProtKB:Q9ERF3, ECO:0000250|UniProtKB:Q9GZS3}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9GZS3}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q9GZS3}.
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DR EMBL; BC074136; AAH74136.1; -; mRNA.
DR RefSeq; NP_001086055.1; NM_001092586.1.
DR RefSeq; XP_018100565.1; XM_018245076.1.
DR AlphaFoldDB; Q6GMD2; -.
DR SMR; Q6GMD2; -.
DR BioGRID; 102647; 1.
DR IntAct; Q6GMD2; 1.
DR DNASU; 444484; -.
DR GeneID; 444484; -.
DR KEGG; xla:444484; -.
DR CTD; 444484; -.
DR Xenbase; XB-GENE-5751613; wdr61.L.
DR OMA; VGFSPCN; -.
DR OrthoDB; 1052423at2759; -.
DR Proteomes; UP000186698; Chromosome 2L.
DR Bgee; 444484; Expressed in oocyte and 19 other tissues.
DR GO; GO:0016593; C:Cdc73/Paf1 complex; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0000791; C:euchromatin; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0055087; C:Ski complex; ISS:UniProtKB.
DR GO; GO:0080182; P:histone H3-K4 trimethylation; ISS:UniProtKB.
DR GO; GO:0045638; P:negative regulation of myeloid cell differentiation; ISS:UniProtKB.
DR GO; GO:0051571; P:positive regulation of histone H3-K4 methylation; ISS:UniProtKB.
DR GO; GO:2001162; P:positive regulation of histone H3-K79 methylation; ISS:UniProtKB.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; ISS:UniProtKB.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..305
FT /note="WD repeat-containing protein 61"
FT /id="PRO_0000245856"
FT REPEAT 14..57
FT /note="WD 1"
FT REPEAT 62..101
FT /note="WD 2"
FT REPEAT 104..143
FT /note="WD 3"
FT REPEAT 146..187
FT /note="WD 4"
FT REPEAT 188..227
FT /note="WD 5"
FT REPEAT 230..269
FT /note="WD 6"
FT REPEAT 272..305
FT /note="WD 7"
SQ SEQUENCE 305 AA; 33334 MW; EF24A7220569F5F2 CRC64;
MSTQYSILFK QEHAHEDAIW SVGWGKNSND GSELVISGSL DDLVKVWKWS DERLEMQWAL
EGHQLGVVSV DVSPSGNIMA SSSLDAHIRL WDLESGKQIR SIDAGPVDAW SVAFSPDSQH
LATGSHVGKV NIFGVETGKK EYSLDTRGKF ILSIAYSPDG KYLASGAIDG IINIFDIATG
KLLHTLEGHA MPIRSLTFST DSQLLVTASD DGYIKIYDVQ HASLAATLSG HGSWVLNVAF
SPDDAHFVSS SSDKSVKVWD VSARTCVHTF LDHQDQVWGV KYNRNGSKIV SVGDDQEIHV
YDCPI