位置:首页 > 蛋白库 > WDR61_XENLA
WDR61_XENLA
ID   WDR61_XENLA             Reviewed;         305 AA.
AC   Q6GMD2;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=WD repeat-containing protein 61;
GN   Name=wdr61;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Component of the PAF1 complex, which at least consists of
CC       CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61 (By similarity). The PAF1
CC       complex interacts with PHF5A (By similarity).
CC       {ECO:0000250|UniProtKB:Q9ERF3, ECO:0000250|UniProtKB:Q9GZS3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9GZS3}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9GZS3}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC074136; AAH74136.1; -; mRNA.
DR   RefSeq; NP_001086055.1; NM_001092586.1.
DR   RefSeq; XP_018100565.1; XM_018245076.1.
DR   AlphaFoldDB; Q6GMD2; -.
DR   SMR; Q6GMD2; -.
DR   BioGRID; 102647; 1.
DR   IntAct; Q6GMD2; 1.
DR   DNASU; 444484; -.
DR   GeneID; 444484; -.
DR   KEGG; xla:444484; -.
DR   CTD; 444484; -.
DR   Xenbase; XB-GENE-5751613; wdr61.L.
DR   OMA; VGFSPCN; -.
DR   OrthoDB; 1052423at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 444484; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0016593; C:Cdc73/Paf1 complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0000791; C:euchromatin; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0055087; C:Ski complex; ISS:UniProtKB.
DR   GO; GO:0080182; P:histone H3-K4 trimethylation; ISS:UniProtKB.
DR   GO; GO:0045638; P:negative regulation of myeloid cell differentiation; ISS:UniProtKB.
DR   GO; GO:0051571; P:positive regulation of histone H3-K4 methylation; ISS:UniProtKB.
DR   GO; GO:2001162; P:positive regulation of histone H3-K79 methylation; ISS:UniProtKB.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..305
FT                   /note="WD repeat-containing protein 61"
FT                   /id="PRO_0000245856"
FT   REPEAT          14..57
FT                   /note="WD 1"
FT   REPEAT          62..101
FT                   /note="WD 2"
FT   REPEAT          104..143
FT                   /note="WD 3"
FT   REPEAT          146..187
FT                   /note="WD 4"
FT   REPEAT          188..227
FT                   /note="WD 5"
FT   REPEAT          230..269
FT                   /note="WD 6"
FT   REPEAT          272..305
FT                   /note="WD 7"
SQ   SEQUENCE   305 AA;  33334 MW;  EF24A7220569F5F2 CRC64;
     MSTQYSILFK QEHAHEDAIW SVGWGKNSND GSELVISGSL DDLVKVWKWS DERLEMQWAL
     EGHQLGVVSV DVSPSGNIMA SSSLDAHIRL WDLESGKQIR SIDAGPVDAW SVAFSPDSQH
     LATGSHVGKV NIFGVETGKK EYSLDTRGKF ILSIAYSPDG KYLASGAIDG IINIFDIATG
     KLLHTLEGHA MPIRSLTFST DSQLLVTASD DGYIKIYDVQ HASLAATLSG HGSWVLNVAF
     SPDDAHFVSS SSDKSVKVWD VSARTCVHTF LDHQDQVWGV KYNRNGSKIV SVGDDQEIHV
     YDCPI
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024