ID   WDR61_XENTR             Reviewed;         305 AA.
AC   Q6PBD6;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=WD repeat-containing protein 61;
GN   Name=wdr61;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Component of the PAF1 complex, which at least consists of
CC       CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61 (By similarity). The PAF1
CC       complex interacts with PHF5A (By similarity).
CC       {ECO:0000250|UniProtKB:Q9ERF3, ECO:0000250|UniProtKB:Q9GZS3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9GZS3}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9GZS3}.
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DR   EMBL; BC059759; AAH59759.1; -; mRNA.
DR   RefSeq; NP_988871.1; NM_203540.1.
DR   AlphaFoldDB; Q6PBD6; -.
DR   SMR; Q6PBD6; -.
DR   STRING; 8364.ENSXETP00000015781; -.
DR   PaxDb; Q6PBD6; -.
DR   DNASU; 394466; -.
DR   GeneID; 394466; -.
DR   KEGG; xtr:394466; -.
DR   CTD; 80349; -.
DR   Xenbase; XB-GENE-5751496; wdr61.
DR   eggNOG; KOG4155; Eukaryota.
DR   HOGENOM; CLU_000288_57_11_1; -.
DR   InParanoid; Q6PBD6; -.
DR   OMA; VGFSPCN; -.
DR   OrthoDB; 1052423at2759; -.
DR   PhylomeDB; Q6PBD6; -.
DR   TreeFam; TF324549; -.
DR   Reactome; R-XTR-429958; mRNA decay by 3' to 5' exoribonuclease.
DR   Reactome; R-XTR-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-XTR-75955; RNA Polymerase II Transcription Elongation.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000009511; Expressed in egg cell and 15 other tissues.
DR   GO; GO:0016593; C:Cdc73/Paf1 complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0000791; C:euchromatin; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0055087; C:Ski complex; ISS:UniProtKB.
DR   GO; GO:0051568; P:histone H3-K4 methylation; IBA:GO_Central.
DR   GO; GO:0080182; P:histone H3-K4 trimethylation; ISS:UniProtKB.
DR   GO; GO:0051571; P:positive regulation of histone H3-K4 methylation; ISS:UniProtKB.
DR   GO; GO:2001162; P:positive regulation of histone H3-K79 methylation; ISS:UniProtKB.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..305
FT                   /note="WD repeat-containing protein 61"
FT                   /id="PRO_0000245857"
FT   REPEAT          14..57
FT                   /note="WD 1"
FT   REPEAT          62..101
FT                   /note="WD 2"
FT   REPEAT          104..143
FT                   /note="WD 3"
FT   REPEAT          146..187
FT                   /note="WD 4"
FT   REPEAT          188..227
FT                   /note="WD 5"
FT   REPEAT          230..269
FT                   /note="WD 6"
FT   REPEAT          272..305
FT                   /note="WD 7"
SQ   SEQUENCE   305 AA;  33257 MW;  E99C68EE9AD89748 CRC64;
     MSTQYSILFK QEHAHEDAIW SVGWGKNSND GSELVISGSL DDLVKVWKWS DERLELQSTL
     EGHQLGVVSV DVSPSGNIMA SSSLDAHIRL WDLESGKQIR AIDAGPVDAW SVAFSPDSQH
     LATGSHVGKV NIFGVETGKK EYSLDTRGKF ILSIAYSPDG KYLASGAIDG IINIFDIATG
     KLLHTLEGHA MPIRSLTFSP DSQLLVTASD DGYIKIYEVQ HASLAATLSG HGSWVLNVAF
     SPDDTHFVSS SSDKSVKVWD VSARTCVHTF LDHQDQVWGV KYNKNGSKIV SVADDQEIHV
     YDCPI